Comparison of the Anti -Diabetic Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) With That of Glibenclamide on Streptozotocin Induced Diabetic Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Diabetes mellitus is a metabolic disorder in which a person has high blood sugar either because the pancreas does not produce enough or because of relative insensitivity of insulin. Cinnamon extract decreases blood glucose level of some experimental animals by increasing glucose uptake in adiposities and by increasing sensitivity of insulin.. Searching to evaluate the anti-diabetic effect of cinnamon (Cinnamomum cassiae) with glibenclamide in experimentally induced diabetic rats.Aim: To find out the anti diabetic effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a stablished antidiabetic drug (Glibenclamide) in streptozotocin induced diabetic rats.Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was desined as 2 parts: Experiment-1 & Experiment – 2. Result: Cinnamon produces no statistically significant effect on blood glucose level of non-diabetic rats ( P- value >0.10; which is not significant).).Cinnamon significantly reduced blood glucose level of streptozotocin induced diabetic rats. There is no statistically significant difference between cinnamon and Glibenclamide on blood glucose lowering effect in streptozotocin induced diabetic rats( P – value >0.10; which is not significant).Conclusion: The study was conducted to find out anti diabetic effect of cinnamon on experimentally induced diabetic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers blood glucose level in experimentally induced diabetic rats. So cinnamon can be used as alternative anti-diabetic medicine for its easy availability, cost effectiveness and as well as lack of significant side effects.
Authors and Affiliations
Sagia Afrose, Md. Ismail Khan, Elisa Omar Eva, Masuma Khanam
Keywords
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- EP ID EP377276
- DOI 10.9790/0853-1707044550.
- Views 66
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