COMPARISON OF THE THERAPEUTIC ACTIONS OF TAURINE, METHYLSULFONYLMETHANE AND SILYMARIN AGAINST ACETAMINOPHEN-INDUCED NEURO- AND HEPATO-TOXICITY IN ADULT MALE ALBINO RATS.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 3
Abstract
To evaluate the neuro- and hepato-curative effects of taurine (TAU) and methylsulfonylmethane (MSM) in acetaminophen- induced neuro- and hepato- toxicity in adult male albino rats. Silymarin (SLN) was used as reference drug. Methods: A total of 40 albino rats were assigned into five groups of 8 rats in each group. Rats was administered a single daily dose of acetaminophen (APAP, 500 mg/kg body weight, p.o) for 14 days. Acetaminophen treated rats were divided into four groups, the positive control group, taurine treated group, MSM treated group and silymarin treated group. The Acetaminophen- intoxicated animals were treated with the tested drugs for two weeks. A group of untreated animals served as negative control. Results: There was significant (P<0.05) increase in levels of liver marker enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the actaminophen- treated rats, compared to the normal control. Moreover, acetaminophen induced oxidative stress in both liver and brain tissues in terms of increased MDA, GSSG and NO contents and decreased GSH; and caused oxidative DNA damage in terms of elevation of 8-hydroxy-2-deoxyguanine (8-OHdG). In brain, acetaminophen (APAP) moderately disturbed the normal levels of DA, NE and serotonin. Both silymarin, taurine and MSM normalized the serum activities of liver marker enzymes (ALT and AST) and restored the normal redox status and ameliorated acetaminophen induced DNA- oxidative damage in liver. In addition, both silymarin, taurine and MSM restored the normal redox status and the normal levels of brain monoamines (DA, NE and 5-HT) and ameliorated acetaminophen induced DNA- oxidative damage in brain. The efficiency of neuro- and hepatocurative effect was SLN> TAU > MSM. Conclusion: the study shows that taurine, silymarin and MSM possess significant neuro- and hepato-curative attribute due to their antioxidant properties. Keywords: Acetaminophen- oxidative stress-liver- brain- silymarin- taurine- MSM.
Authors and Affiliations
Omyma K. Radwan
Keywords
Related Articles
- EP ID EP418255
- DOI -
- Views 117
- Downloads 0
COMPARATIVE STUDY ON ANTI-INFLAMMATORY SYNERGISTIC ACTIVITY OF LORNOXICAM USING TURMERIC OIL IN TDDS
The present research work was an attempt to develop, evaluate matrix-type transdermal therapeutic system containing lornoxicam with hydrophilic polymer (HPMC E-5) and turmeric oil (leaf extract) by the solvent evaporatio...
Nanotheranostic: Nanomedicine and future development
Nanotechnology holds a productive potential about to happen explored as a multifunctional word of light at end of tunnel for a wide alps of biological and engineering applications a cleanly known as molecular sensors for...
Interaction of phospholipase enzymes with autophagic processes; importance for cell signaling and therapeutics
Phospholipases are inherently involved in signalling mechanisms of various neurotransmitters and hormones. Cytosolic phospholipase (cPLA2) initiates pro-inflammatory lipid mediator pathways which play a critical role in...
NUTRIGENOMICS: A NEW PARADIGM FOR REVEALING PERIODONTAL INTERRELATIONSHIPS
Improved understanding of the mechanism behind periodontal tissue devastation, the potential protective role of nutrients and the advent of modern genomic measurement tools have led to an increased interest in the associ...
HISTOPATHOLOGICAL CHANGES IN ADHATODA VASICA TREATED MICE STOMACH AFTER GAMMA-IRRADIATION.
In the present study, Adhatoda vasica extract administered and radiation induced changes in the stomach of Swiss Albino male mice were studied. Animals were divided into four groups: Group I containing normal mice served...