Comparison of two Different Dosages of Tranexamic Acid in Spine Fixation Surgery: A Randomized, Prospective Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction: Perioperative use of tranexamic acid (TXA) in major spine surgeries is known to reduce blood loss and thereby decrease the need for blood transfusion. However the optimal dosing of TXA remains highly controversial. This study was designed to compare the outcome in terms of blood loss and amount of blood transfusion needed in two groups of patients undergoing multilevel lumbar spine fixation surgeries receiving two different doses of TXA. Methodology:A total of sixty patients undergoing multilevel spine fixation surgery were divided equally into two groups and randomized to receive either a low dose of TXA: Group A (15mg/kg loading dose followed by 1mg/kg/hr maintenance infusion) or a high dose of TXA: Group B (30 mg/kg loading dose followed by 2mg/kg/hr maintenance infusion). Outcome measures will be perioperative blood loss, postoperative haemoglobin and haematocrit levels and amount of blood transfused. Results:The mean perioperative blood loss was significantly higher in group A when compared to the Group B. Also, the postoperative haemoglobin level was higher in group B. However, TXA did not significantly reduce transfusion requirements. Conclusion:Higher dose TXA can significantly reduce the perioperative blood loss when compared to low dose TXA.
Authors and Affiliations
Dr. Seena Solomon, Dr. Kishan Shetty
Keywords
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- DOI 10.9790/0853-1609042933
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