Comparison of Ykl-40 In Patients With &Without Gestational Diabetes Mellitus In The First Trimester &At Weeks 24 –28
Journal Title: Acta Medica Ruha - Year 2023, Vol 1, Issue 3
Abstract
Objective:To elucidate whether the YKL-40 level in the first trimester is effective in predicting the development of diabetes in pregnant groups with and without gestational diabetes mellitus.Methods:All first-trimester pregnant cases between the ages of 18 –35 years who applied to the obstetrics and gynecology outpatient clinic of Antalya Training and Research Hospital with a single pregnancy, who did not have additional diseases and fetal anomalies, were included in the study (n=250). An oral glucose tolerance test of 75 gr (OGTT) was performed weekly to diagnose GDM in all pregnant women 24 –28. During the administration of OGTT, fasting venous blood was taken to check the level of YKL-40. Results:A total of 250 patients have been enrolled within the scope of this study. According to the results of OGTT, 18 individuals were diagnosed with GDM. Notably, while there was a difference in YKL-40 measurements in all patients, buts no difference in sub-group analysis. The differences between the first YKL-40, second YKL-40, and YKL-40 difference values of patients with and without GDM were evaluated. There was no statistically significant difference between the first, second, and YKL-40 difference values of patients with and without GDM (p>0.05).Conclusion:Regarding the results of this research, YKL-40 might be valuable in detecting low-grade inflammation in pregnant women. However, there is a need for larger-scale prospective randomized studies from the early period to the end of pregnancy to better and more accurately evaluate the relationship between insulin resistance and inflammation.
Authors and Affiliations
Neslihan Erkal
Keywords
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