Compliance for Transdermal Fentanyl Patch versus Sustained Release Oral Morphine in Cancer Pain
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction: Cancer pain management is an art as it needs to be individualized according to the type and site of cancer and variability of response among patients to different pain medications and treatments. The emergence of the concept of 'total pain' alleviation emphasizes both on physical and psychological factors to improve the overall quality of life and decrease the work loss and disability. This study was done at a tertiary cancer care centre of North India. Material and methods: 40 patients with moderate to severe cancer pain were randomized into two equal groups. Group-A received 75 μg/hr Fentanyl patches to be changed at 72 hours and Group B received 30 mg sustained release oral morphine tablet 12 hourly. This study was done on outdoor patient basis in patients having VAS scores >6 according to WHO regime. VAS, incidence of break through pain, compliance and adverse effect were noted. For breakthrough pain fixed dose of 10 mg immediate release morphine was used with 4 hr locking period. The study period was 12 weeks. Results: Incidence of breakthrough pain and adverse effects were more in group B patients having VAS score >8. Compliance in fentanyl patch group was poor in patients who belong to low socio-economic status, villagers and illiterate. Conclusion: Fentanyl patch provided better quality and intensity of analgesia with fewer adverse effect than morphine but compliance in villagers and illiterate patients was poor.
Authors and Affiliations
Sharad Singh, Neena Raizada, Nitu Nigam, Aditya Elhence, Gaurav . , SN Prasad
Keywords
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