COMPLIMENT RECEPTOR TYPE - 1 (CD35) GENE POLYMORPHISM AND PLASMODIUM FALCIPERUM MALERIA
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 2
Abstract
Malaria is a most causative agent for worldwide death. Plasmodium falciperum infected malaria most dangerous than other plasmodium species. It has closely association to compliment receptor type -1 (CD35) gene polymorphism. CD35 (CR1) is a cell surface receptor for plasmodium falciperum containing PfEMP-1 as a legend. Density of CD35 on erythrocyte can be determined by CR1 allele (HH, HL, and LL). HH allele of CR1 gene express high density of CD35 whereas LL in low density. High density of CD35 is more susceptible to falciperum infection. CD35 is also responsible for sever malaria. During plasmodium infection, pro-inflammatory cytokine like TNF-α, IFN-γ levels are increased. The elevated ratio of TNF-α/IL10 indicates falciperum infection. Cell adhesion protein like VCAM, ICAM also mediate the malarial infection.
Authors and Affiliations
Rishabh Dev Saket| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India, Corresponding author email: rdev47@gmail.com, Shrikant Kol| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India, Arvind Kumar Tripathi| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India, Sher Singh Parihar| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India, Jitendra Kumar Tipathi| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India, Ugam Kumari Chauhan| Department: Centre for Biotechnology studies, Awadhesh Pratap Singh University, Rewa (M.P.), India
Keywords
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- EP ID EP11412
- DOI 10.5958/2319-5886.2015.00078.8
- Views 270
- Downloads 14
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