Composition Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 2
Abstract
Association between type 2 diabetes (T2DM) and compositional changes in the gut micro biota is established, however little is known about the dysbiosis in early stages of Prediabetes (preDM). The purpose of this investigation is to elucidate the characteristics of the gut micro biome in preDM and T2DM, compared to Non-Diabetic (nonDM) subjects. Forty nine subjects were recruited for this study, 15 nonDM, 20 preDM and 14 T2DM. Bacterial community composition and diversity were investigated in fecalDNA samples using Illumina sequencing of the V4 region within the 16S rRNA gene. The five most abundant phyla identified were: Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia, and Actinobacteria. Class Chloracido bacteria was increased in preDM compared to T2DM (p=0.04). An unknown genus from family Pseudonocardiaceae was significantly present in preDM group compared to theothers (p= 0.04). Genus Collinsella, and an unknown genus belonging to family Enterobacteriaceae were both found to be significantly increased in T2DM compared to the other groups (Collinsella, and p= 0.03, Enterobacteriaceae genus p= 0.02). PERMANOVA and Mantel tests performed did not reveal a relationship between overall composition and diagnosis group or HbA1C level. This study identified dysbiosis associated with both preDM and T2DM, specifically at the class and genus levels suggesting that earlier treatment in preDM could possibly have an impact on the intestinal micro flora transitioning to T2DM.
Authors and Affiliations
Vallabh Shah
Keywords
Related Articles
- EP ID EP417824
- DOI 10.15436/2376-0949.15.031
- Views 143
- Downloads 0
NAFLD Susceptibility Genes and Their Association with Type 2 Diabetes and Obesity in a New Mexico Population
Objective: Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) that increase the risk of developing non-alcoholic fatty liver disease (NAFLD). One purpose of this study was to determine...
Comparative Efficiency of Sulfonylurea and/or Dipeptidyl Peptidase-4 inhibitor in Basal-Supported Oral Therapy in Japanese Patients with Type 2 Diabetes (JDDM39)
Basal-supported Oral Therapy BOT comprising treatment with oral antidiabetic drugs and once-daily injections of a long-acting insulin analog is a convenient regimen However it sometimes fails to achieve satisfactor...
Effect of Obesity on the Time Required Achieving a FEO2 of 90% during Preoxygenation
An end-expiratory oxygen (FEO2) concentration > 90% is desirable prior to tracheal intubation. We hypothesized that the time required for pre oxygenation to achieve an FEO2 of 90% was related to patient Body Mass Index (...
Occurrence of Left Ventricular Hypertrophy in Subjects with Metabolic Syndrome: Role of Adiponectin
This study was designed to evaluate the role of total plasma adiponectin ADPN on the occurrence of left ventricular hypertrophy in subjects with metabolic syndrome MetS compared to a control group without MetS The m...
Effect of Bariatric Surgery on Glycemic Control in a Military Training Facilitytary Training Facility
Background: The objective of the study was to evaluate the effects of gastric bypass surgery on diabetic and pre-diabetic patients. Outcome variables were diabetic status, BMI, and if patients were able to discontinue pr...