Abstract

Background: Nowadays, bone grafting is used in both human and veterinary orthopedics to stimulate fracture healing, accelerate joint union, and restore bone defects. In such procedures, orthopedic surgeons are studying a favorable substitute for bone autograft. The present study aimed to evaluate theranekron and hydroxyapatite effects on bone healing in rabbit model. Methods: First, 20 rabbits were prepared and divided into four groups of five. In theranecron group (T), theranecrone was injected to the bone defect site on days 3, 7, and 10 a􀅌er surgery, the other group was left empty as the control group, in the third group, a combination of theranekron and hydroxyapatite (T&H) was filled in the defect site, and in the fourth group hydroxyapatite was implanted alone (H). Radiographs were taken on days 14, 28, 42, 56 from rabbit's hand after surgery in lateral view. At the end of the study, histopathological samples were taken from injured areas of radius. Results: In radiographical and histopathological evaluations, T&H group had the best and the control group the weakest healing performance. Conclusion: T and T&H groups were better than two other groups in terms of bone healing criteria, according to radiological and histopathological evaluation.

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