Consumption of Aqueous Leaf Extract of OcimumgratissimumImpairs Haematological Function in Wistar Rats
Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 7
Abstract
Abstract: There have been conflicting reports by researchers on the effect of aqueous leaf extract of Ocimumgratissimum (OG) on haematological parameters This study was carried out to evaluate the dose-dependent effect of OG leaf extracton some haematological parameters in wistar rats. Twenty-four male rats were randomly assigned into four groups of six rats each. Group 1 was a control while groups 2, 3 and 4 were test groups (T1 – T3) and were given 450mg/kg, 800mg/kg and 1800mg/kg respectively of OG leaf extract daily for 30 days. All rats had free access to water and rat chow. Results showed a significantly decreased RBC count in T2 (p<0.05) and T3 (p<0.01) compared with control. Platelet count and PCV were significantly decreased in T3 (p<0.05) compared with control. A significant increase in total WBC count was observed in T1 (p<0.05) and T2 (p<0.01) when compared with control. A significant reduction in neutrophil count in T1 (p<0.05), T2 (p< 0.05) and T3 (p<0.01)compared with control was observed. Lymphocyte count was significantly increased in T1 (p<0.05), T2 (p<0.01) and T3 (p<0.01) compared with control. There was no significant difference in MCV, MCH and MCHC in the different groups. In conclusion, aqueous leaf extract of Ocimumgratissimumcaused reduction in RBC count, PCV, platelet count and neutrophil count but caused increases in total WBC count and lymphocyte count. Keywords: Ocimumgratissmum, haematological parameters, aqueous leaf extract.
Authors and Affiliations
Aribo EO, Udefa AL
Keywords
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