Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 1
Abstract
The development of zero-order release systems capable of delivering drug(s) over extended periods of time is deemed necessary for a variety of biomedical applications. We hereby describe a simple, yet versatile, delivery platform based on physically cross-linked poly(vinyl alcohol) (PVA) microgels (cross-linked via repetitive freeze/thaw cycling) containing entrapped dexamethasone-loaded poly(lacticco-glycolic acid) (PLGA) microspheres for controlled delivery over a 1-month period. The incorporation of polyacids, such as humic acids, Nafion, and poly(acrylic acid), was found to be crucial for attaining approximately zero-order release kinetics, releasing 60% to 75% of dexamethasone within 1 month. Microspheres alone entrapped in the PVA hydrogel resulted in negligible drug release during the 1-month period of investigation. On the basis of a comprehensive evaluation of the structure-property relationships of these hydrogel/microsphere composites, in conjunction with their in vitro release performance, it was concluded that these polyacids segregate on the PLGA microsphere surfaces and thereby result in localized acidity. These surface-associated polyacids appear to cause acid-assisted hydrolysis to occur from the surface inwards. Such systems show potential for a variety of localized controlled drug delivery applications such as coatings for implantable devices.
Authors and Affiliations
Izabela Galeska, Tae-Kyoung Kim, Siddhesh D. Patil, Upkar Bhardwaj, Debjit Chatttopadhyay, Fotios Papadimitrakopoulos, Diane J. Burgess
Keywords
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- EP ID EP681871
- DOI 10.1208/aapsj070122
- Views 105
- Downloads 0
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