CONTROVERSIAL ROLE OF ANTIPSYCHOTICS IN THE TREATMENT OF ALZHEIMER’S DISEASE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 4
Abstract
Antipsychotics are the commonly prescribed drugs in the treatment of Alzheimer’s disease, which is the most common form of dementia. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment in relieving the depression, psychotic symptoms (hallucinations and delusions) and behavioral disturbances (physical and verbal aggression, motor hyperactivity, repetitive mannerisms and activities, and combativeness). But several placebo studies & clinical based evidences which recorded the deaths of the patients concluded that this medication nearly doubles the risk of death in patients over two to three years by developing cerebrovascular adverse events, upper respiratory infections, oedema or extra pyramidal symptoms. The use of selective serotonin reuptake inhibitors (SSRI’s), Nor- epinephrine reuptake inhibitors (NERI’s) and Tricyclic antidepressants (TCA’S) may relieve depression but still they are associated with serious adverse effects such as insomnia, agitation, confusion and GI adverse effects. So there is a need for applying non-pharmacological treatment i.e. Psychotherapy rather than the Pharmacotherapy in minimizing the symptoms & anticipates further research in developing the appropriate medication, alternative to the antipsychotics which minimizes the suffering of the patient. Typical antipsychotics were the first generation of the drugs aimed to treat psychosis by antagonizing D2 receptors. As a result, they reduce dopaminergic neurotransmission in the four dopamine pathways. Typical Antipsychotics include Chlorpromazine, Chlorprothixene, and Haloperidol etc. Atypical Antipsychotics are the drugs which not only block dopamine receptors but also serotonin receptors.Risperidone, Olanzapine, Quetiapine, Aripiprazole, Clozapine, Ziprasidone include Atypical Antipsychotics.
Authors and Affiliations
Mahesh G, G Praveen kumar
Keywords
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