Correlation between atherogenic risk and adiponectin in gestational diabetes mellitus
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 1
Abstract
Introduction and objective. Gestational diabetes mellitus (GDM) is a pregnancy complication which increases the risk for maternal and foetal complications during pregnancy, and also significantly increases the cardiovascular risk for women’s health in the postpartum. Current literature provides contradictory information on the role of adiponectin (AdipoQ) in the course of GDM. The aim of the study was to measure AdipoQ concentration in blood of women with GDM and to find correlations between this adipokine and clinical and biochemical parameters of the atherogenic risk.Material and methods. The GDM group included 50 women diagnosed with GDM between 24 – 28 weeks of gestation who underwent routine prenatal tests for GDM in compliance with the guidelines of the Polish Diabetes Association. All patients underwent clinical and laboratory evaluation at GDM diagnosis. Laboratory tests included serum AdipoQ concentration, fasting glucose and insulin, OGTT, lipid parameters, C-reactive protein and fibrinogen in serum.Results. The GDM group showed significantly elevated fasting glucose, insulin, HOMA-IR values, total cholesterol, LDLcholesterol and triglicerydes as compared with the control group (p<0.05). The atherogenic index, CRP, fibrinogen in women with GDM were significantly higher than in the control group (p<0.05). AdipoQ concentrations did not differ significantly between the groups during gestation (p=0.7054). No correlations, except with the neonatal weight (r= – 0.29, p<0.05), were found between AdipoQ and the studied parameters.Conclusions. Based on the conducted studies, it may be conclude that women with early diagnosed and promptly treated GDM have a normal adiponectin level, although insulin resistant changes and increased cardiovascular risk in basic metabolic parameters are observed. Moreover, adiponectin does not reflect the atherogenic risk in pregnant women with GDM.
Authors and Affiliations
Beata Matyjaszek-Matuszek, Monika Lenart-Lipińska, Jolanta Kowalczyk-Bołtuć, Wojciech Szlichtyng, Tomasz Paszkowski
Keywords
Related Articles
- EP ID EP80753
- DOI -
- Views 137
- Downloads 0
The influence of passive and active moral training on medical university on changes of students’ moral competence index – results from randomized single blinded trial
Introduction and Objectives. Human’s life as well as medical professions consist of many moral dilemmas. The aim of our study was to evaluate moral competences of midwifery students during their whole university educatio...
Risk of tick-borne diseases in various categories of employment among forestry workers in eastern Poland
Among the zoonotic agents causing occupational diseases, those transmitted by ticks are very important, in particular the spirochetes [i]Borrelia burgdorferi[/i] which are the common cause of occupational Lyme borreliosi...
Cardiohepatic interactions – cirrhotic cardiomyopathy and cardiac cirrhosis
Interactions between the heart and the liver have been under investigation for many years. Cirrhotic cardiomyopathy characterized by hyperdynamic and hyporeactive circulation has been described in patients with advanced...
Co-infection with Borrelia species and other tick-borne pathogens in humans: two cases from Poland.
Co-infection with Borrelia species and Anaplasma phagocytophilum or Babesia spp. was assessed in a retrospective study of tick-exposed individuals from southeastern Poland. The co-infection rate of these pathogens was fo...
Microtissue density prognostic factor evaluation based on antigens CD34 and CD 105 in ovarian cancer patients
Uncontrollable cell division and disorders of the apoptotic processes constitute the key phenomena in cancer transformation. The theory that the tumour growth above critical density is possible due to creation of the new...