Correlation between Histopathological Type and Grade of Different Ovarian Tumors with Their Blood CA125 Levels
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Introduction: Women with ovarian carcinoma experience poor survival because symptoms are vague and diagnosis is unlikely at an early stage. Early detection is utmost important both for treatment and survival CA-125 is the most frequently used biomarker for ovarian cancer detection. In this study, the authors evaluated 60 distinct cases of benign and malignant primary ovarian tumors, of different cell lines and degrees of differentiation, aimed at assessing the relationship between serum levels of CA125 and the biological behavior and/or the histological degree of these neoplasms. Materials & Methods: patients were selected for study after clinical suspicion fallowed by radiological evaluation .Serum sample for CA 125 sent preoperatively. Patients were operated and ovarian tissue sent for histopathological examination for typing and grading in pathology department. The study carried out with sixty patients for one year duration. Results: After histopathological examination it was confirmed that 37 (61.6%) cases were suffering from benign ovarian tumor. 6 (10%) cases were suffering from borderline ovarian tumor and 17 (28.3%) cases from malignant ovarian tumor. Majority of patients with benign tumor (35/37, 94.59%) have their serum CA125 value <35 U/ml and most of patients with borderline & malignant tumors (18/23, 78.2%) have their serum CA125 value >35 U/ml. Again 7/17 (41.17%) of patients with malignant tumor have their serum CA125 value > 100 U/ml. 100% of patient with borderline tumors have their serum CA125 value in between 35-65 U/ml. The present study revealed that 100% of the patient having epithelial borderline/malignant tumors of grade I had their serum CA125 values within 35-65 U/ml. (6/7, 85.7%) of patients having epithelial borderline/ malignant tumor of grade III had their serum CA125 values >100 U/ml. Another important finding was that epithelial malignant tumor including Mucinous cystadenocarcinoma, Serous cystadenocarcinoma had their mean value more than 100 IU. Conclusion: Patients with borderline/malignant epithelial tumor had higher pre-operative serum CA125 value (>35U/ml) than benign ovarian tumors.CA125 had ascending relation with higher grade of tumor. With very high value of serum CA 125, one should think about serous or mucinous epithelial ovarian tumor.
Authors and Affiliations
Dr. Samir Kumar Roy
Keywords
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