Correlation between insulin resistance and metabolic syndrome in obesity adolescents
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 1
Abstract
The prevalence of obesity and the metabolic syndrome increased significantly in developing countries. Insulin resistance is considered to be the central pathophysiologic factor in development of the metabolic syndrome. Several factors are known to increase insulin sensitivity, namely obesity, gender, perinatal factors, puberty, sedentary lifestyle and diet. The aim of this study was to determine the correlation between component of metabolic syndrome and insulin resistance in obesity adolescents. This study was a cross-sectional design conducted in adolescents in Tondano city Minahasa distric, on February - April 2013, involving a total 160 adolescents with obesity. Anthropometric measurements including height measurement (HM), body weight (BW), waist circumference (WC) and blood pressure and laboratory tests such as lipid profile, plasma glucose level and HOMA-IR. Determination of metabolic syndrome using the IDF criteria, 2007. Data analyzed using univariate, bivariate and Pearson correlation test. Data was analyzed with SPSS software version 22, p value <0.05 was considered significant. There were 160 subjects collected in this study who have met the inclusion criteria. All subjects had experienced abdominal obesity as much as 26.9% among males with WC ≥ 90 cm and 73.1% females with WC ≥ 80 cm.A total of 14.4% of the subjects had TG ≥150 mg / dL, and 100% subjects had HDL < 40 mg / dL for males and females<50 mg / dL. A total of 4.4% of the subjects who already had a FBS ≥100 mg / dL, 29.4% had had a blood pressure systolic≥ 130 mmHg and 21.9% blood pressure diastolic ≥ 85 mmHg. In addition, as many as 2.4% of the subjects had insulin resistance (IR). Multiple regression analysis showed, among the components of metabolic syndrome, waist circumference (p = 0.006), triglycerides (p = 0.013), and FBS (p= 0.000) are the MS component that contributes to the HOMA-IR. The high prevalence of the metabolic syndrome and their correlation with insulin resistance in obese adolescents provides evidence for prevention against the risk morbidity and mortality of degenerative diseases, especially type II diabetes and cardiovascular disease. Keywords: insulin resistance, metabolic syndrome, adolescent.
Authors and Affiliations
Aaltje E. Manampiring
Keywords
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