Correlation between isolated-check visual evoked potential and optical coherence tomography angiography in early diagnosis of primary open-angle glaucoma
Journal Title: Eye Science (Yanke Xuebao) - Year 2020, Vol 35, Issue 6
Abstract
[Objective:] To analyze and evaluate the correlation between the isolated-check visual evoked potential (IC-VEP) and optical coherence tomography angiography (OCTA) in early diagnosis of primary open-angle glaucoma (POAG) and provide theoretical evidence for improving the efficiency of diagnosis in early POAG. [Methods:] A clinical case-control study. Thirty-one eyes of 31 patients with early stage of POAG (observation group) and 30 eyes of 30 normal individuals (control group) were retrospectively collected in Shijiazhuang People's Hospital from March 2018 to April 2019. The age was (43.11±5.34) years and (42.88±5.15) years in the observation group and control group, respectively. The visual field, IC-VEP, and OCTA were performed for all subjects. The baseline data were statistically analyzed between two groups. The correlation and the changes in signal-to-noise (SNR) and peripapillary capillary density were analyzed, and the diagnostic efficacy was evaluated. [Results:] There was no statistical significance in gender, age, best corrected visual acuity, refractive diopter, and central corneal thickness between two groups (all P>0.05). Statistical significance was found in MD between two groups (P<0.05). The sensitivity and specificity of IC-VEP and peripapillary capillary density in early POAG patients were 83.87%and 90%, 87.1% and 86.67%, respectively. No statistical significance was observed (P>0.05). The detection rate of consistency was 67.21% between two groups. The SNR values in the observation and control groups were 0.92±0.05 and 1.37±0.16, with statistical significance between two groups (t=3.15, P=0.004). In the observation group, the peripapillary capillary density was notably decreased (P<0.05). Positive correlation was noted between SNR and peripapillary capillary density in the observation group (r=0.79, P<0.001). [Conclusion:] The consistent changes in the visual evoked potential and OCTA at the early stage of POAG will further improve the early diagnostic efficiency and rate of POAG and reduce the blindness rate of glaucoma.
Authors and Affiliations
Hengli ZHANG, Shuning LI, Xiaowei YAN, Yulei GENG, Lihua MA, Fan LI, Guangxian TANG
Keywords
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- EP ID EP763448
- DOI 10.3978/j.issn.1000-4432.2020.12.08
- Views 14
- Downloads 0
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