Correlation between low density lipoprotein subtype and acute cerebral infarction in patients with type 2 diabetes mellitus
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 12
Abstract
Objective To investigate the relationship between low density lipoprotein (LDL) subtypes and acute cerebral infarction (ACI) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on 292 T2DM patients admitted to Nanjing Jiangbei Hospital from October 2020 to December 2022. According to the brain magnetic resonance examination results, the patients were divided into T2DM without ACI group (group A,n=157) and T2DM with ACI group (group B,n=135). High resolution polyacrylamide gel electrophoresis and automatic biochemical analyzer (Beckman AU5800) were used to measure the levels of each LDL subtype and total cholesterol (TC) of the two groups of subjects, and compare the differences of blood lipids among the groups under traditional risk factors. Logistic regression analysis was used to identify risk factors for T2DM combined with ACI. Results The LDL2, LDL3, LDL4, LDL5, TC, LDL in group B were significantly higher than those in group A (P＜0.05). Multivariate logistic regression analysis showed that elder age, hypertension, high levels of LDL2 and LDL4 were independent risk factors for T2DM complicated with ACI; The ROC curve showed an AUC of 0.843. Conclusion Compared with simple T2DM, the level of LDL2, LDL3, LDL4, and LDL5 are significantly increased in T2DM combined with ACI, and high levels of LDL2 and LDL4 may be independent risk factors for T2DM patients combined with ACI.
Authors and Affiliations
ZHANG Renhe, YUAN Tailei, WANG Yurong, WANG Yan
Keywords
Related Articles
- EP ID EP753811
- DOI 10.13429/j.cnki.cjcr.2024.12.015
- Views 34
- Downloads 0
Effects of intergenerational support from children on depression in rural empty nesters
Objective To explore the relationship between intergenerational support from children and depressive symptoms among rural empty-nesters, with a view to providing a reference basis for depression prevention and treatment...
Protective effect of esketamine on hepatic ischemia-reperfusion injury
Esketamine, as a perioperative sedative and analgesic drug, has been widely used in Europe and America. However, the protective effect of esketamine on the liver during the perioperative period is still in the applicated...
Diagnostic value of plasma chromogranin A levels for pheochromocytoma
"<b>Objective</b> To investigate the role of plasma chromogranin A (CgA) and free metanephrines (MNs) levels in the diagnosis of pheochromocytoma (PHEO). <b>Methods</b> The clinical data of 26 patients with PHEO (PHE...
Analysis of risk factors for delayed postoperative discharge of patients with pulmonary nodules
<b>Objective</b> To investigate the influencing factors of delayed postoperative discharge in patients with pulmonary nodules. <b>Methods</b> Electronic medical records of 223 patients, 91 males and 132 females, who...
Progress in clinical application of esketamine in pediatric anesthesia
Ketamine is a commonly used anesthetic drug, but its clinical use declined in the late 1990s due to its postoperative nightmares, extrapyramidal syndrome, and a tendency to abuse. As an isomer of ketamine, esketamine is...