Correlation of Glycemic Status with Plasma Fibrinogen Level in Insulin Dependent as Well as Noninsulin Dependent Diabetic Patients
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 5
Abstract
Aims and objective: Fibrinogen is an indicator of an inflammatory vascular changes and endothelial dysfunction. It has been identified as an independent risk factor for cardiovascular disease and it is closely associated with traditional cardiovascular risk factors. Diabetic patients have higher cardiovascular morbidity than non -diabetic individuals. Patients with diabetes mellitus have 2 to 4 times increased risk for cardiovascular disease than non-diabetic patients. Several studies have shown that haemostatic factor especially hyperfibrinogenemia is implicated as a source of atherosclerotic changes and its complications. Fibrinogen which is an acute phase protein plays a key role in the pathogenesis of atherosclerosis and complication of atherothombosis disease. Pathogenesis of noninsulin dependent diabetes mellitus (NIDDM), widely known as type 2 diabetes is observed to closely relate with acute phase response which is predominately cytokine mediated. The role of inflammation in insulin dependent type 1 diabetes (IDDM) is still contradictory. By estimating circulating fibrinogen in NIDDM and IDDM patients, we tried to establish this hypothesis. Methods: Freshly diagnosed twelve IDDM cases, twenty-five NIDDM cases and twenty-five NIDDM cases under oral hypoglycemic agent for at least 5 years were selected for this study and were estimated their glycemic status and the level of fibrinogen. Thirty normal controls were also selected. Results: Freshly diagnosed IDDM and NIDDM cases showed significantly higher levels of the fibrinogen in compare to control. Plasma fibrinogen was higher and had positive correlation with increased duration of diabetes. NIDDM cases had slightly elevated values of fibrinogen in compared to the IDDM cases. There are no significant change of fibrinogen level is found in NIDDM cases after treating by oral hypoglycemic drugs for at least 5years in compare of freshly diagnosed NIDDM cases. Conclusion: By evaluating the plasma level of fibrinogen in different categories it can be postulated that NIDDM patients had a higher plasma fibrinogen level in compare to control. Fibrinogen level was significantly correlated with glycemic control. This line of pathological basis should be further explored for diagnosis, management and follow up.
Authors and Affiliations
Shamim Shaikh Mohiuddin
Keywords
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- EP ID EP413641
- DOI 10.15226/2374-6890/5/5/001117
- Views 143
- Downloads 0
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