Correlation of Histological Tumour Grade and Hormonal Receptor Status In Infiltrating Ductal Carcinoma Breast- A Referral Centre Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Breast cancer is the one of the most common malignancy in females worldwide apart from cervical cancer and more than 1 million women are diagnosed with breast cancer each year [1]. Most cases of invasive carcinoma breast are ductal in origin (over 90%) with invasive ductal carcinoma of no special type not otherwise specified (NOS) accounting for nearly 70% of all cases [2]. Although, incidence of breast cancer is low in India as compared to western countries, it is associated with poor prognosis and high mortality, may be due to late presentation when it is in advanced stages [3]. Breast carcinoma shows heterogeneity in its clinical behavior with several features having prognostic significance; including histologic subtype, grade, lymph node status, estrogen receptor (ER)/progesterone receptor (PR) status, human epidermal growth factor receptor-2/neu (her-2/neu) status, proliferative activity and DNA content, growth factors and its receptors, oncogenes, and tumor suppressor genes [4]. At present, ER status is regarded as the most powerful predictive marker in the treatment of breast cancer and it is well known fact that strong ER-positive cases benefit from endocrine therapy alone [5,6] ; even though ER and PR are codependent variables.[2]. Her-2 neu overexpression is a useful parameter to predict response to herceptin, but it is not a good predictor of response to chemotherapy or overall survival [2,3]. With introduction of adjuvant hormonal or chemotherapeutic regimens, determination of the hormonal receptor status in breast cancer has become practice as positive status confers survival advantage in these patients [5,7]. Hormone receptors study is not routinely measured as it is expensive and is still considered a research tool in many parts of our country [4,7]. This could adversely impact decision making regarding treatment protocol and sometimes patients are treated empirically with tamoxifen which is not always required. The present study was planned keeping in mind predictive importance of receptor status for the prognosis of illness and application of appropriate therapy. The objective was to determine receptor status and it′s correlation with histopathological grade of the invasive ductal carcinoma (NOS) type in an Indian population.
Authors and Affiliations
Dr. Rigvardhan
Keywords
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