Correlation of Testosterone levels with progression of Amyotrophic Lateral Sclerosis in Males: A Cross-Sectional Study.
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2019, Vol 37, Issue 37
Abstract
The known higher incidence of Amyotrophic Lateral Sclerosis (ALS) in men and older age suggests a role of sex steroidal hormones in the disease process. Animal models of ALS have shown lower levels of plasma testosterone. Testosterone is known to exert neuroprotective and neurotrophic actions on neurons. Our objective was to study the association of total testosterone (TT) levels with disease severity on ALS Functional Rating Scale-Revised (ALS FRS-R) scale and King’s Staging. This cross-sectional study included 64 males with definite/probable ALS. Patients’ morning plasma TT levels were tested, and ALS FRS-R and King’s Staging was marked. Standard score was used to compare the deviation of patients’ TT levels from average TT levels of age matched healthy males. A scatter plot was constructed, and correlation analysis was performed using Spearman’s Rank Correlation. 39/64 patients (60.9 %) had TT levels that were lower by 1/more standard deviation, than age matched average levels in healthy men. There was a statistically significant positive correlation of TT levels with ALS FRS-R (r=.326, p=0.009) and negative correlation with King’s Staging (r=-.312, p=0.012). Thus, with declining function and disease progression, standard scores of TT levels decreased. Maintaining plasma TT levels, as close to age matched average levels, may be explored as an adjuvant therapy in ALS.
Authors and Affiliations
Hemangi Sane, Ritu Varghese, Amruta Paranjape, Reena Jain, Nandini Gokulchandran, Prerna Badhe, Alok Sharma
Keywords
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