Correlation of Virulence Determinants of Staphylococcus aureus to the Severity of Diabetic Foot Ulcers in a Tertiary Care Centre, Egypt
Journal Title: Microbiology Research Journal International - Year 2017, Vol 20, Issue 6
Abstract
Aim: This study aimed to estimate the correlation of the Staphylococcus aureus virulence determinants to the severity of the diabetic foot ulcers in patients admitted to diabetic foot Unit at Mansoura University Hospitals. Study Design: A prospective study was performed. Place of Study and Duration: This study was performed in diabetic foot Unit of Mansoura University hospital, Egypt. Methodology: The study included 95 patients clinically diagnosed with diabetic foot ulcers from whom swabs were obtained from the foot lesions to be processed followed by detecting virulence determinants in isolated S. aureus by PCR. Results: Staphylococcus aureus was isolated from 34 cases (35.8%). icaA, icaD, pvl and tst genes were detected in 61.8%, 67.6%, 53%, and 32.4% of S. aureus isolates respectively with higher prevalence in isolated strains from more severe infections and results were stastically significant. coa and clfA genes were positive 97.1% and 94.1% isolates respectively. Conclusion: The results showed that the S. aureus strains causing infections in diabetic foot patients having genes: icaA, icaD, pvl and tst may be correlated to the severity of lesions whereas coa and clfA were not.
Authors and Affiliations
Yasmin Nabiel, Ghada Barakat
Keywords
Related Articles
- EP ID EP315908
- DOI 10.9734/MRJI/2017/34789
- Views 118
- Downloads 0
Anti-Coccidiosis Potential of Autoclaveable Antimicrobial Peptides from Xenorhabdus budapestensis Resistant to Proteolytic (Pepsin, Trypsin) Digestion Based on In vitro Studies
Aims: To elucidate the anticoccidial potential of antimicrobial peptides from Xenorhabdus budapestensis on both causative pathogens (prokaryotic Clostridium perfringens and eukaryotic Eimeria tenella). Objectives: (1) T...
Antibiotic Resistance Patterns of Lactic Acid Bacteria Isolated From Different Fermented Milk Products of Turkish Origin
Aims: Lactic acid bacteria isolated from 48 Turkish fermented milk products obtained from local markets, dairies or bazaars were investigated for their resistance of antibiotics including ampicillin, erythromycin, gentam...
Distribution and Diversity of Indigenous Trichoderma species in Machakos County, Kenya
Aim: This study was undertaken in order to determine the effect of land-use intensification on occurrence, distribution, and diversity of Trichoderma fungus. Study Design: Cross-sectional study. Place and Distribution o...
Prevalence and Microbial Resistance of Uropathogenic Bacteria Isolated from Neonatal and Pediatric Patients in Western of Iran
Backgrounds: Urinary tract infections (UTIs) are the most common bacterial infections disease among children, pediatric and neonatal patients. These infections are found frequently in children. The global evolution of an...
Biosorption of Heavy Metals in Dumpsite Leachate by Metal-resistant Bacteria Isolated from Abule-egba Dumpsite, Lagos State, Nigeria
Aim: We studied the potentials of four metal-resistant bacterial strains to reduce the concentration of selected metals in dumpsite leachate. Methods: The bacteria which were obtained from the culture collection of the E...