Correlation study between body mass index, body fat, glycemic indices and lipid profile with insulin resistence and secretion in healthy euthyroid individuals
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Insulin resistance and secretion are highly dependent on variable influencing factors, in the developmental process of Diabetes mellitus. Growing incidence of diabetes prompt us to study the various contributing factors in the development of Diabetes mellitus in healthy individuals. Objective: To study the relationship associated between anthropometric measurements, plasma lipids, glycemic indices, thyroid stimulating hormone with Insulin resistance and secretion in healthy individuals. Materials and Methods: A cross-sectional study was conducted in normal healthy individuals, from general population.(n=142).Body mass index, body fat, were measured, Glycemic indices, fasting glucose, post prondial glucose, Glycated hemoglobin, fasting insulin levels, Thyroid stimulating hormone, fasting lipid profile were analysed. Result: Insulin resistance (HOMA IR) is positively correlated with Glycemic indices (FBS, PPBG, HbA1C) P<0.05, Body mass index P<0.05, Body fat P<0.05, and Cholesterol/HDL ratio. Serum Thyroid Stimulating Hormone (TSH) P<0.05 is negatively associated with Insulin Secretion. Glycemic Indices, Triacylglycerol, cholesterol, LDL are negatively correlated with Insulin Secretion. Conclusions: Glycemic indices, body mass index, body fat and lipid profile are intrinsically related to Insulin resistance and Insulin secretion. Increased TSH is associated with decreased insulin secretion leading to increase blood glucose levels, which indicates that thyroid hormone is important for pro insulin expression and translation, providing the evidence that, effects of thyroid hormones on carbohydrate metabolism also include the control of proinsulin gene expression, the possible role of thyroid hormones on insulin secretion.
Authors and Affiliations
Mohammad Ibrahim Shaik, Mohammad Siddique Ahmed Khan
Keywords
Related Articles
- EP ID EP472102
- DOI 10.18231/2394-6377.2018.0020
- Views 62
- Downloads 0
A study of serum magnesium and dyslipidemia in type 2 diabetes mellitus patients
Background: Type 2 diabetes is a heterogeneous metabolic disease characterised by insulin resistance in peripheral tissue together with impaired insulin secretion. It affects more than 285 million peoples worldwide and e...
A study of serum levels of magnesium and C-Reactive Protein in Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (DM) has emerged as a major public health issue associated with various complications. Patients with metabolic syndrome (MS) have increased risk of developing cardiovascular disease and type 2 di...
A comparative study of serum estrogen and lipid profile in pre-menopausal and post-menopausal women as atherosclerotic risk factors
Objectives: Menopause is the permanent cessation of menstruation; since cardiovascular disease is the leading cause of death among post-menopausal women, which may be due to lower level of estrogen. The present study was...
Liver enzymes and glycemic control markers in uncontrolled type 2 diabetes mellitus- A case control study
Introduction: Mild increase in liver enzymes, may be a marker for significant liver injury. The increased transaminases and hepatomegaly are found to be reversible with glycemic control. Objectives: 1. To compare the liv...
A study of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in women of Polycystic Ovarian Disease (PCOD) at Tertiary Care Hospital of Gujarat, India
Introduction: Polycystic ovarian disease (PCOS) is one of the most common female endocrine disorders. PCOD produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be...