Correlative study of in-hospital clinical outcomes with N terminal – pro B type natriuretic peptide and glycated hemoglobin in acute myocardial infarction
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 4
Abstract
Background and Objectives: Early risk stratification, in cases of acute myocardial infarction(AMI) is essential to treat high risk patients aggressively, to reduce the morbidity and mortality. In this study we assess the short term prognostic value of N terminal pro B type natriuretic peptide (NT pro BNP), Glycated Hemoglobin (HbA1c), measured at admission, in cases of AMI. Methods: A total of 100 patients, presenting to R L Jalappa Narayana Hrudayalaya Heart Center, will be included into the study. Patients were evaluated with history, physical, electrocardiogram, cardiac markers, NT pro BNP, HbA1c and Echocardiogram. These patients were observed over a period of 7 days in hospital. Patients were monitored for adverse outcomes like heart failure, arrhythmias, reinfarction, mitral regurgitation and any other complications. NT pro BNP values ranged widely from <20 pg/ml to 2000 pg/ml, a value of 125pg/ml in age < 75y and >450 pg/ml in age >75 y was considered abnormal. HbA1c level of >6.5% was considered abnormal. Results: There was a significant negative correlation observed between NT pro BNP and Left ventricular ejection fraction at p – 0.0001. Total of 27 cases developed complications like heart failure, reinfarction, mitral regurgitation which was significantly associated with abnormal NT pro BNP values at p – 0.002. Total 6 patients had died although the NT pro BNP values were elevated in all the cases there was no statistically significant association between NT pro BNP values and mortality. HbA1c was not found to be significantly associated with LVEF, adverse out comes and mortality in short term. Conclusion: NT pro BNP is a strong predictor of in hospital adverse cardiac events. HbA1c was not an independent predictor of short-term outcomes.
Authors and Affiliations
B Sunil Abhishek, B N Raghavendra Prasad
Keywords
Related Articles
- EP ID EP205059
- DOI -
- Views 117
- Downloads 0
A study of intradermal testing with aeroallergens in patients with chronic urticaria in a tertiary care centre
Background: Chronic urticaria affects upto 1% of the population, and in most cases lesions occur spontaneously without an obvious identifiable external cause. Numerous articles have been published citing the role of aero...
Role of MRI in the evaluation of status epilepticus
The role of Diffusion Weighted Magnetic Resonance Imaging in the evaluation of various intracranial lesions has been evolving and increasing since its initial introduction as newer uses are being explored constantly. We...
The cervical extension of human fetal thymus
Introduction: Thymus is a primary central lymphoid organ, responsible for provision of the T- lymphocytes to the entire body. It is a soft bilobed organ consisting of a pair of laterally compressed, more or less pyramida...
Comparative study for treatment of great saphenous varicose vein by stripping versus multiple ligations
Background: Varicose veins are a routinely encountered in routine surgical practice. Their presentation varies from pure cosmetic, symptomatic to active ulceration. Improved socioeconomic status in modern society have re...
Medical students perception on assignment based learning in biochemistry
Background: Student learning should be assessed during the course formatively as well as summatively. For students to demonstrate the application of higher order cognitive thinking and for better reinforcement and retent...