Coxsakie B virus among type 1diabetic Sudanese children
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 3
Abstract
Background: Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells. Infection by Coxsackievirus B virus has been linked to the onset of type 1 diabetes; however its precise role has not been elucidated yet. Objective: The aim of this study was to detect the seroprevalance of group B CoxsackievirusIgG antibodies, and to determine the relationship between the presence of antibodies and certain factors such as (Duration, family history, a report of symptoms). Methods: A total of 54 blood samples (29 paediatric diabetic cases and 25 non diabetic children as controls) who attending to Omdurman Children Hospital, Ahmed Gasim Children Hospital, during the period from September – October 2014, were enrolled in this study. 54 serum specimens were collected from Paediatric diabetic and non-diabetic children, and analysed by ELISA technique. Results: The results showed that in the whole study sample, there were 61% (n=33) group B CoxsackievirusIgG positive; there were 39% (n=21) group B CoxsackievirusIgG negative. Of the 29 diabetic cases, there were 68.97% (n=20) positive for group B CoxsackievirusIgG, and 31.03% (n=9) negative for group B CoxsackievirusIgG. On the other hand, of the 25 non diabetic controls, we found 52% (n=12) positive for group B CoxsackievirusIgG, and 48% (n=13) negative for group B CoxsackievirusIgG. Conclusion: Statistical analysis showed that no association between a positive ELISA test in a diabetic child and a report of fever, reporting a family history, or longer duration of illness. Further research is needed on serological specimens with larger sample size. Keywords: Type 1 diabetes; Coxsackievirus B virus; children; IgGantibodies
Authors and Affiliations
Salma Suliman OsmanElhag
Keywords
Related Articles
- EP ID EP418307
- DOI -
- Views 124
- Downloads 0
“A Large Incidentally-Diagnosed Left-Lobed Hepatic Hydatid Cyst in a Young Male Patient”
Introduction: Despite modern healthcare facilities, hydatid disease (HD) remains a perpetuating public health problem in endemic countries. Infection with Echinococcus may have a diverse clinical evolution, leading even...
PREPARATION AND IN VITRO EVALUATION OF ORAL LIPOSPHERE OF CANDESARTAN CILEXETIL
Liposphere was prepared by melt dispersion method. At first Lipid phase lipids (eg; glycerylmonostearate (GMS), Compritol 888, Precirol ATO 5, stearic acid, Dynasan 116) and drug was taken in a beaker and was melted at 7...
Effect of heat sterilization on surface characteristics of two different Niti rotary systems – A SEM study
Rotary nickel-titanium instruments have attained great popularity because of their high flexibility, increased elastic limits and better resistance to bending and torsional failure compared to stainless steel instruments...
Synthesis, Charectrisation of Novel Indole Based Derivatives Used as Medicinally Potent Agents
A large number of compounds containing indole nucleus have been patented, as chemotherapeutic agents, antimicrobial, cytotoxic, anti-inflammatory, antitumor, anti-convulsant, antitubercular and anti-HIV. A wide range of...
Drug Utilization Pattern of Anesthetics in a Tertiary care Hospital
Background: Anesthesia means ‘loss of sensation’. Medications that cause anesthesia are called anesthetics. Anesthetics are used during tests and surgical operations to induce sleep, which prevents pain and discomfort an...