Creatinine estimation by compensated Jaffe method and enzymatic method - A comparative study
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 5, Issue 1
Abstract
Background: Chronic Kidney Disease is a global threat to health particularly for developing countries, since therapy is expensive and life-long. Incidence of CKD has doubled in the last 15 years. Accurate creatinine measurement is essential in the diagnosis of chronic kidney disease as serum creatinine is used for estimating glomerular filtration rate. The aim of our study was to compare the analytical performance between the enzymatic method and compensated Jaffe method for estimation of creatinine. Methods: In our study we measured serum creatinine in 135 serum samples by both enzymatic and compensated Jaffe methods using Cobas c311 automated analyser. Results: Relationship between both the methods using Cobas c311 automated analyser showed a correlation coefficient of 0.999, which means these two methods correlate very well. Conclusion: There was a good agreement and comparability between compensated Jaffe and enzymatic methods except for a minimal variation at higher concentrations of creatinine.
Authors and Affiliations
D Merriwin, P M Abraham Sam Rajan, N Ananthi
Study of uric acid levels among patients with myocardial infarction (MI) attending a teaching hospital
Aim: The present study aimed to assess the correlation of serum uric acid levels with CK-MB in patients with MI attending a teaching hospital. Methods: A total of 50 study subjects with MI were selected for this study an...
Study of association between Hypothyroidism and kidney dysfunction
Thyroid hormones have a significant impact on kidney health and disease. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and Glomerular filtration rate. Several stu...
Assessment of thyroid dysfunction among diabetic patients attending to a rural teaching hospital
Aim: The present study aimed to find out the prevalence of thyroid dysfunction among diabetic patients in a rural teaching hospital. Materials and Methods: Two hundred twenty (220 cases) known diabetic patients who atten...
Serodiagnosis of tuberculosis by indigenously developed antibody detection with Indirect ELISA
Background: India is the country with the highest burden of tuberculosis (TB). The World Health Organization (WHO) TB statistics for India for 2016 give an estimated incidence figure of 2.79 million cases of TB for India...
A study of correlation between lipid peroxide and lipid profile in diabetic patients
Aims and Objectives: To Study Correlation between Lipid Peroxide and Lipid profile in Diabetic Patients. Methodology: Participants of the study group were selected from the outpatients population of Department of Diabeto...