Cu-GnRH – new gonadoliberin (GnRH) analog
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Our research was concentrated about physiological and structural aspects of metal complexes with GnRH, which were synthetized by Professor Henryk Kozłowski from the Uniwersity of Wrocław. We found that copper, nickel, zinc and cobalt complexes with GnRH stimulated the release of LH and FSH both in vivo and in vitro. The most stable and active was Cu-GnRH. It also exhibited the higher affinity to specific receptor than GnRH, had higher releasing power for LH and FSH and stimulated differently the intracellular signaling. We suggest, that this complex in highly promissive as a new analog of GnRH with possibleapplication to further research.
Authors and Affiliations
Kazimierz Kochman
Keywords
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