Cytotoxic and antioxidant activity of selected marine sponges
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 3
Abstract
Objective: To evaluate the anticancer activity of the crude extracts of Rhabdastrella globostellata (R. globostellata) and Spirastrella inconstans (S. inconstans) var. moeandrina Dendy. Methods: Soxhlet extraction method was used to extract the secondary metabolites and various assays antioxidant, anticancer and various assays were carried out. The extract were tested anticancer activity against a HeLa, Raw 264.7 and Hek-293. Results: The sponge extracts tested exhibited from median to high toxicity in at least one of the toxicity bioassays performed. The antioxidant activity of the isolated metabolite in ethylacetate solution was assessed by SOD and GTH assays and compared with that of other known natural antioxidants. Conclusions: Potent antioxidants have been detected among both phenolic metabolites and alkaloids. Antioxidant effects of tested compounds have been attributed to their action as chain-breaking antioxidants and/or as scavengers of radicals
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