Cytotoxic Assessment of Quinoline Based Derivatives on Liver Cancer Cell Line
Journal Title: Pakistan Biomedical Journal - Year 2018, Vol 1, Issue 2
Abstract
Current scenario of newer diseases with multiple causes has drawn the attention of the researchers in the field of therapeutics and they are now inclined to identify molecules effective for targeted therapy Objective: Quinoline (1-azanaphthalene); belongs to heterocyclic aromatic nitrogen compound. Some quinoline-based derivatives are also known for their anti-tumor activity. The study was planned to evaluate the cytotoxic potential of quinoline derivatives Methods: Berberine; a quinoline compound was made part of study to make structural analogs which were docked against potential target proteins. Cytotoxic profiling of all derivatives was done using MTT cytotoxicity assay. Results: The pharmacoinformatic and structure activity relationship studies of analogs were done. The cytotoxic profiles were elucidated by comparing viability rates of analogs treated hepatic cancerous cell line with untreated hepatic cells and untreated mesenchymal stem cells as standards. Marked cytotoxicity was seen in all molecules at low doses than reported in past studies with relevance to parent compound. Conclusions: The results will be further confirmed through various other cell culture assays targeting different marker proteins, pharmacoinformatics tools and structure activity relationship studies.
Authors and Affiliations
Maria Fareed1*, MH Qazi1, Sarfaraz Ahmed2, Sana Awan2 and Aamer Qazi2
Keywords
Related Articles
- EP ID EP694167
- DOI https://doi.org/10.52229/pbmj.v1i2.43
- Views 159
- Downloads 0
Signicance of Philadelphia Chromosome in Chronic Myeloid Leukemia Patients of Anmol Hospital, Lahore, Pakistan
Chronic myelogenous Leukemia is (Clonal stem cell disorder) cancer which starts in bone marrow a soft tissue inside bones that aids to form blood cells. It is rst form of cancer that was rstly recognize to associate stro...
Impact of abolishment of PMDC on Basic Medical & Dental Sciences Faculty Career Path of a Federally Chartered Public Sector Medical University- A Questionnaire Validation Study
Ascertain validity of a questionnaire which measures the impact of abolishment of PM&DC on Basic Medical & Dental Sciences Faculty Career Path of a Federally Chartered Public Sector Medical University. Methods: Cro...
Prognostic Signicance of Cellular Iron Metabolism in Breast Cancer
Breast carcinoma is among the most common malignancy in women. Abstract: Objective: Aim of the present study was to evaluate the prognostic signicance of iron expression in the biopsies of patients with breast cancer...
Novel Bioactive Compound Production by Microbial Biota: Potential Antimicrobials
Man is always trying to make his life easier and accomplished. He has faced mass destruction in history due to epidemics like small pox, malaria and plague. In order to combat diseases, exploration of man led him to sear...
Iron deficiency and risk of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a subset of head and neck squamous cell carcinoma caused by excessive substance abuse like alcohol, tobacco etc. Objectives: Aim of the present study was to evaluate the iro...