DELTA-TOCOTRIENOL IS THE MOST BIOACTIVE ANTICANCER AGENT AGAINST GASTRIC CANCER
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 11
Abstract
This study evaluated the anticancer activity of δ-tocotrienol (DT3), a bioactive form of vitamin E, in the inhibition of gastric cancer growth and survival compared with other three forms α-, β- and ϒ-tocotrienol (AT3, BT3 and GT3). DT3 is the most bioactive form of vitamin E in inhibiting the cell proliferation of non-metastatic (AGS) and metastatic (746T) gastric cancer cells followed by GT3 and BT3. However, AT3 is devoid of any inhibitory effect on gastric cancer cell viability. The estimated IC50 values are 80+5, 55+5 and 40+5 μM for BT3, GT3 and DT3, respectively in both cell lines. DT3 (40 μM) significantly inhibited malignant transformation (p <0.02, p <0.01), cell migration (p <0.01) and invasion (p < 0.05, p < 0.02) compared to vehicle in AGS and 746T cells. DT3 inhibited markers for epithelial (E-cadherin) to mesenchymal (vimentin) transition (EMT), metastasis (matrix metalloproteinase 9 [MMP9]), angiogenesis (Vascular endothelial growth factor [VEGF]), inflammation (Nuclear factor-kappa B [NF-kB]), and Wnt signaling (β-catenin) and its downstream transcriptional targets C-MYC, Cyclin D1 and survivin compared to vehicle. In addition DT3 also induced apoptosis in gastric cancer cells (AGS and 746T). Taken together, these data demonstrate that DT3 is a potential therapeutic agent in advanced gastric cancer and warrants further investigation for its clinical use in the prevention and treatment of gastric cancer.
Authors and Affiliations
Dr. Kazim Husain
Keywords
Related Articles
- EP ID EP656422
- DOI -
- Views 161
- Downloads 0
A CRITICAL UNDERSTANDING OF LOKA PURUSHA SAMYA VADA IN MAINTAINING THE INTEGRITY OF SUKRAVAHA SROTAS
Vajikarana tantra, the science which deals with the male reproductive system has a very crucial place in the present life scenario. In the fast life of present day, most of the people adopt to junk foods which lack many...
TOXICITY STUDY OF THE AQUEOUS EXTRACT OF TEUCRIUM CAPITATUM L AND SILENE VULGARIS OF THE EL HAJEB REGION (CENTRAL MOROCCO)
In this study, we studied the acute toxicity of the aqueous extract of two plants Teucrium capitatum L and Silene vulgaris, selected from an ethnobotanical study of the EL HAJEB region (Morocco), followed by a phytochemi...
BREAST CANCER IN MEN ABOUT NINE CASES MANAGED AT THE MOHAMED VI CENTER FOR ONCOGYNECOLOGY
Breast cancer in men is a rare disease. Risk factors are many and varied. The diagnosis is made at a later age than in women and at a later stage. The clinical presentation of the disease differs a little in men. All his...
TOXICITY EVALUATION OF NANOCONSTRUCT OF CHITOSAN AND TRIPOLYPHOSPHATE (TPP)
The prefix “nano” has found in last decade an ever-increasing application to different fields of the knowledge.[1] Nanoscience, nanotechnology, nanomaterials or nanochemistry are only a few of the new nano-containing ter...
CONCEPTUAL STUDY OF RAKTAMOKSHANA - A LITERATURE REVIEW
Raktamokshana therapy is the blood cleansing & purification therapy. Ancient Indian texts have talked varies procedures that can cause immense Shodhana or purification of the body. Among the five cardinal Shodhana karmas...