Denosumab For The Treatment Of Bisphosphonate-Refractory Hypercalcemia Of Malignancy - A Case Report
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 2
Abstract
Hypercalcemia of malignancy caused primarily by tumor-induced bone resorption may lead to renal failure, coma, and death. Patients treated with routine intravenous bisphosphonates may not respond or may relapse on therapy. Denosumab, a monoclonal human antibody which binds to RANKL, inhibits the osteoclast-mediated bone resorption and hypercalcemia. We report a case of hypercalcemia in a patient with metastatic carcinoma breast refractory to bisphosphonate therapy responding to denosumab and to the best of our knowledge is the first reported case in Indian literature.
Authors and Affiliations
Vishal V Ramteke, Sudhir R Dash, Shubhadeep Bose, Ritu Jain
Keywords
Related Articles
- EP ID EP432588
- DOI -
- Views 61
- Downloads 0
Addition of Fentanyl to Hyperbaric Bupivacaine in spinal anesthesia for Caesarian section – effect on dose of local anesthetic and duration of postoperative analgesia – a randomized comparative study
Background: Spinal anesthesia is commonly used for the caesarian section for its reliability and ease of administration. However, it is limited by fixed duration of anesthesia, hypotension and lesser control of block hei...
Decline in Beta-Cell Function among Adolescents with Type 2 Diabetes Mellitus
It is well known that beta-cell function declines over time in adults with type 2 diabetes mellitus (T2DM). The beta-cell dysfunction, initially characterized by impairment in the first phase of insulin secretion followi...
Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis
Objective: The clinical experience with single intra-articular hyaluronic acid injection in knee OA is limited. The aim was to assess the therapeutic efficacy, tolerability and adverse events of single-shot intra-articul...
Hepatitis in Developing Countries: Still a Scourge.
Screening is defined as the application of a diagnostic test to an asymptomatic population in order to detect a disease at a stage when intervention may improve its outcome and natural history.1 In simpler terms, screeni...
Evaluation of acridine orange staining of uncentrifuged urine as a screening method for diagnosis of urinary tract infection
The term urinary tract infection (UTI) encompasses a variety of clinical entities, including asymptomatic bacteriuria (ASB), cystitis, prostatitis, and pyelonephritis 1. UTIs are the leading cause of gram-negative sepsis...