Denosumab Related Osteonecrosis of the Jaws as Consequence of Osteoporosis Treatment- A Case Series
Journal Title: Saudi Journal of Oral and Dental Research - Year 2017, Vol 2, Issue 8
Abstract
Abstract: Bisphosphonate-related osteonecrosis of the jaws represents a widely studied pathology. Moreover, some cases of ONJ related to the use of Denosumab have also been described recently. Denosumab is a human monoclonal antibody. It is bound with high affinity and specificity to nuclear factor kappa beta activating factor ligand (RANKL) and prevents Rank activation with reduction bone reabsorption. However, medium and long term effects of this drug are not unknown yet. The main goal of the present report is twofold. First, we point out the serious complications that these drugs might provoke. Second, we describe four cases of Denosumab related ONJ in order to expand the knowledge about the proper management of this rare complication. Keywords: Denosumab, osteonecrosis of the jaw, osteoporosis, conservative treatment
Authors and Affiliations
Sánchez López Jose Dario, Cariati Paolo, Pérez de Perceval Tara Miguel, Monsalve Iglesias Fernando, Rodríguez Ismael
Keywords
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