Design and development of Candesartan cilexetil emulsomal drug delivery systems for the effective management of cardiovascular diseases
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
The main objective of this research work was to formulate candesartan cilexetil emulsomes (AT2 receptor antagonist) for percutaneous administration for sustaining the drug release and reducing the particle size up to nanolevel leading to better therapy. The compatibility studies of candesartan cilexetil, Glyceryl behenate (Campritol), Soyalecithin and the physical mixture were conducted using I.R spectroscopy. The results revealed that the peaks obtained for candesartan cilexetil pure samples and physical mixture were to be compatible and without changes in the functionalities indicating their compatibility. Candesartan cilexetil emulsomes were formulated by varying the concentrations of glyceryl behenate (0.25-1.0%) and Phosphatidylcholine (0.3-1.6%) by employing thin film hydration technique followed by emulsification followed and high speed homogenization. The formulations were found to be reproducible. When subjected to evaluation, formulation F6 possessed the maximum entrapment efficiency. In-vitro permeation studies of candesartan cilexetil emulsomes revealed that the drug release from all the formulations followed First-order kinetics and ascertained peppas mechanism & F5, F6 and F7 ascertained higuchi’s mechanism respectively. Application of Korsmeyer-peppas equation to the data of all the formulations revealed that the mechanism of candesartan cilexetil emulsomes was governed by predominant non-Fickian diffusion and case –II transport. The average particle size rage of optimized formulation was found to be 116.4 nm well within the emulsomal range. The zeta potential value of the optimized formulation was found to be -27.5 mv indicating high negative surface change leading to greater stability. Based on the above statement the formulation F6 was considered as better formulation for the effective management of cardiovascular diseases.
Authors and Affiliations
Malla Vasavi Chandrika, Medarametla Kishore Babu
Keywords
Related Articles
- EP ID EP33235
- DOI -
- Views 292
- Downloads 0
Investigation of physiochemical and vegetative properties of two barley lines
Physiochemical and vegetative properties of two barely lines in “EBYT88-17 AND EBTY88-20” purchased from agriculture center of Golestan Province, Iran were investigated for enzyme activity, sprouting energy and suitabil...
Comparative studies on in vitro antimicrobial and antioxidant activity of Acacia sinuata crude extract and their synthesized silver nanoparticles
In the present scenario the research and analysis of nanoparticles synthesis with plant extracts and their biological activities has been expanded significantly. Among the agents used for synthesis, silver (Ag) is the...
Phytochemical evaluation of Cassia tora, Caesalpinia bonducela, Tecoma capensis.
In the present study, an attempt was made to investigate phytochemical evaluation of Cassia tora, Caesalpinia bonducela, Tecoma capnensis. The crude drug powder extracts of the leaves of the above plants were taken for...
The study of anti-diabetic activity of aqueous extract of root of Gynandropsis gynandra in diabetic rats
It has been planned to explore the hypoglycaemic and antihyperglycaemic activity of aqueous extract of root of Gynandropsis gynandra herb in normal and diabetic rats.The extract was evaluated for its specific physical...
Design and evaluation of diffusion controlled extended release matrix tablets of Ropinirole hydrochloride
The present work was aimed to develop an extended release matrix tablet formulation of Ropinirole hydrochloride by Melt Granulation technique using lipid waxes like stearic acid and hydrogenated castor oil in combinati...