Design and evaluation of lafutidine floating tablets for controlled release by using semi-synthetic and natural polymer
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 12
Abstract
Lafutidine is H2-receptor antagonist. The prepared tablets of various formulations were evaluated for a total floating time, buoyancy lag time, and percentage drug released. Guar gum is an efficient matrix forming agent in floating tablets by generating gas. Drug release from the prepared tablets was slowed over more 12 h and depended on the composition of guar gum and sodium bicarbonate. Lafutidine release was diffusion controlled and follows zero order kinetics. In case of F3 formulation non-fickian diffusion was the drug release mechanism from the prepared lafutidine floating tablets.
Authors and Affiliations
D. Lohithasu*| GITAM Institute of Pharmacy, GITAM University, Visakhapatnam- 530045, India., D. Midhun kumar| A.U. College of Pharmaceutical Sciences, Visakhapatnam- 530003, India., Hemasundara Rao. I| Sri Sai College of Pharmacy, Seetharampuram, Vizianagaram- 535005, India.
Keywords
Related Articles
- EP ID EP1552
- DOI -
- Views 440
- Downloads 24
FLOATING DRUG DELIVERY SYSTEM: A REVIEW
Floating drug delivery systems (FDDS) was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiolog...
Formulation Development and evaluation of ibuprofen sustained release matrix tablet using Lepidium Sativum mucilage
Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drugs (NSAID) available in the market. The objective of present study was to prepare and evaluate sustained release matrix tablets of ibuprof...
Study of Possible Correlation between Pancreatitis and Daily Consumption of Catha edulis in Experimental Animals
Khat (Catha edulis) is widely used throughout the world especially in Yemen and East Africa; It becomes a serious public health phenomena in Yemen that affects the health features of life. The present study evaluates the...
INDUSTRIAL PROCESS VALIDATION: A REVIEW
Validation is defined in the supplementary information section of the Federal Register as “a QA function that helps ensure drug product quality by providing documented evidence that the manufacturing process consistentl...
HERBAL PLANT USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY
The use of traditional medicine is expanding to new horizons and plants still remain as the novel source of structurally important compounds that lead to the development of innovative drugs. India has about 45,000 plant...