DESIGN AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF MANIDIPINE FOR ENHANCEMENT OF SOLUBILITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
Objective: The present work is aimed at developing liquid self-nanoemulsifying drug delivery system (liquid-SNEDDS) of manidipine. Methods: The manidipine SNEDDS is formulated with excipients comprising Capmul MCM as oil phase, Transcutol P as surfactant, and Lutrol L 300 as cosurfactant. The prepared fifteen formulations of manidipine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies. Ternary phase diagram plotted using Chemix software. Results: The optimized manidipine liquid SNEDDS formulation (F14) subjected to drug-excipient compatibility studies by Fourier-transform infrared spectroscopy and characterized for particle size, zeta potential, scanning electron microscopy, and stability studies. The morphology of manidipine SNEDDS indicates spherical shape with uniform particle distribution. The percentage drug release from optimized formulation F14 (98.24±5.14%) was higher than that of pure drug (39.17±2.98%). The stability data indicated no noticeable change in drug content, emulsifying properties, drug release, and appearance. Conclusion: Hence, a potential SNEDDS formulation of manidipine developed with enhanced solubility, dissolution rate, and bioavailability.
Authors and Affiliations
SRIKANTH REDDY S , SURESH G
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 5-ARYLIDENE-2-IMINO-3-(2- PHENYL- 1,8-NAPHTHYRIDIN-3-YL)THIAZOLIDIN-4-ONES
Objectives: Nowadays, antimicrobial resistance represents one of the most significant challenges in the medical community. To overcome the problem, it requires the discovery of newer safe and effective molecules against...
ALTERED AUTONOMIC BALANCE IN NORMAL TENSION GLAUCOMA
Objective: To study autonomic imbalance if any in normal tension glaucoma (NTG)patients by heart rate variability (HRV)and head-up tilt (HUT)test.Methods: The study subjects of age between 45 and 65 years of either sex c...
IDENTIFICATION OF BACTERIA CAUSING NECROTIC PULP WITH 16S rRNA GENE POLYMERASE CHAIN REACTION AND ANTIBIOTIC RESISTANCE TESTING AT THE DENTAL HOSPITAL IN SEKELOA, BANDUNG, INDONESIA
Objective: This study aims to identify the bacteria that cause necrotic pulp in teeth of dental patients and test resistance of the bacteria found to antibiotics. Methods: Bacteria were taken with paper points that were...
EFFECTS OF PHENOLIC COMPOUNDS EXTRACTED FROM SALVIA FRIGIDA ON INDUCED HYPERURICEMIA IN MICE
Objective: The aim of this study was to investigate effects of phenolic compounds rich fraction extracted from aerial parts of Salvia frigida on serum uric acid (SUA) and xanthine oxidase (XOD) in hyperuricemic mice mode...
EVALUATION OF ANTIBACTERIAL, ANTIOXIDANT, AND ANTICANCER POTENTIALS FROM MARINE RED ALGAE GRACILARIA CORTICATA
Objective: The present study was to evaluate the biological activity of Red algae, Gracilaria corticata, collected from the southeast coast of Mandapam, Ramanathapuram, Tamil Nadu. Seaweeds are rich in bioactive compound...