DESIGN AND IN-VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF REPAGLINIDE
Journal Title: International Journal of Pharmaceutical Science and Technology - Year 2010, Vol 4, Issue 1
Abstract
The goal of the present investigation was to design and evaluate mucoadhesive buccal tablet of Repaglinide for the treatment of diabetes (Type-II Diabetes mellitus). The tablets were prepared by using different polymers like Carbopol 934P, Hydroxy Propyl Methyl Cellulose (HPMC K4M), Sodium Carboxy Methyl Cellulose (NaCMC) and Hydroxy Ethyl Cellulose (HEC) as mucoadhesive polymer. Total nine formulations were developed with varying concentration of polymers. The carbopol 934P was used as primary polymer because of excellent mucoadhesive property and secondary polymer like HPMC K4M, NaCMC and HEC were used. The tablets were evaluated for hardness, thickness, weight variation, content uniformity, surface pH, swelling index, bio-adhesive strength, stability studies and in-vitro drug release. FTIR studies showed no evidence on interaction between drug and polymers. The surface pH, bio-adhesive strength and swelling index were found to be 6.5, 36.5gm and 99.53% respectively. Formulation F7 showed maximum drug release of 98.2% in 6 hour. The mechanism and order of drug release from the tablets were non-fickian diffusion and first order kinetics respectively. The results indicate that, the suitable mucoadhesive buccal tablets with desired properties could be prepared.
Authors and Affiliations
Satyabrata B, Ellaiah P, Sujit Martha, Singh Pravind, Panigrahi Bhusan, Debajyoti Das
Keywords
Related Articles
- EP ID EP113362
- DOI -
- Views 161
- Downloads 0
CELLULAR INTERNALIZATION OF NANOPARTICLES
Nanoparticles are becoming popular with drug delivery and drug targeting in cell biology because of their ability to overcome cellular barriers, ease to manufacture, stability, drug release pattern in controlled and sust...
ROLES OF FLAVONOIDS IN PLANTS
Flavonoids are the low molecular weight polyphenolic secondary metabolic compounds, universally distributed in green plant kingdom, located in cell vacuoles. Flavonoids play a variety of biological activities in plants,...
DEVELOPMENT AND IN VITRO EVALUATION OF FILM COATED MICRONIZED IMMEDIATE RELEASE TABLETS OF URSODEOXYCHOLIC ACID
Ursodeoxycholic acid (UDCA) belongs to Biopharmaceutical Classification System (BCS) class II and hence it exhibits low aqueous solubility and high permeability. Solubility of this drug is very low which affects in low...
U.V. SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF HYDROCHLOROTHIAZIDE AND RAMIPRIL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORMS
A simple UV spectrophotometric method was developed for the determination of Hydrochlorothiazide and Ramipril (Ipca Laboratories Ltd) in pure and its pharmaceutical formulations. Hydrochlorothiazide (Ipca Laboratories Lt...
POLLUTION CONTROL ACTS AND REGULATIONS OF INDIA: IN RELATION TO PHARMA-FIELD
Environmental transformation is as old as the history of human development and the nature has been adapting to these changes to keep our ecosystem healthy and habitable. During the past 100 years the developments has b...