DESIGN, FORMULATION AND CHARACTERIZATION OF TENOFOVIR MICROEMULSION AS ORAL DRUG DELIVERY
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
The aim of the present research was to design, formulate and evaluate Tenofovir Microemulsion. Tenofovir, a Nucleotide Reverse transcriptase inhibitor belongs to the category of anti retro viral drug. The oral bioavailability of Tenofovir is 25% due to its poor water solubility. An attempt was made to enhance solubility by formulating oral Microemulsion of Tenofovir. The solubility of Tenofovir in various Oils, Surfactants and Cosurfactants were checked to optimize the components of Microemulsion. Pseudo ternary diagrams were constructed to identify the area of Microemulsion region. A Microemulsion system with oleic acid as Oil phase, Tween 20 as surfactant and Ethanol as Cosurfactant was developed for oral delivery of Tenofovir. To achieve the objective of present study, Microemulsion formulations were prepared by using different ratios of Oil, Surfactant: Cosurfactant and Water. The prepared formulations of Tenofovir were characterized for thermo dynamic stability studies, pH, transparency, viscosity, drug content and in vitro drug release. Particle size and Zeta potential of optimized formulation were found to be 54.30nm and -5.61mV. Among four formulations, TME4 shows highest drug release of 86.88%. The invitro release was found to follow Non-fickian diffusion mechanism. These results demonstrate the potential use of Microemulsion for improving the Bioavailability of poor water soluble compound Tenofovir.
Authors and Affiliations
Divya A*, , CH. Praveen Kumar , K. Gnanaprakash , M. Gobinath
Keywords
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