Design, prediction of bioactivity by physicochemical parameters and Synthesis of Schiff bases of 8-Amino chromone derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 7
Abstract
Drug-design and synthesis leading to the Drug discovery is the area of thirst today. The prediction of the bioassay of the drug before synthesis is treated as the novel approach in drug design. Chromones have drawn the attention of many pharmacologists because of their good biological activities like anti-cancer, antioxidant, antimicrobial, antibiotic, anti HIV, and as good vasodilators and were preferred due to their less mammalian toxicity. In this paper, the authors presented the synthesis and antimicrobial activities of Schiff bases of some chromones. The Schiff base is an important class of chemicals which acts as good intermediates for synthesis of many drugs. Schiff bases of 8-amino-7-hydroxy-2 methyl (or phenyl)-3-methyl chromones 4(ad) with a series of selected aldehydes 5(a-c) were synthesized. The synthesized compounds 8- ((phenylimino)methyl)-7-hydroxy-3-methyl-2-phenyl)-4H-Chromen-4-one, 6(a-l) were formed. The newly synthesized compounds were characterized by spectral analysis like IR, NMR and Mass spectrometry.
Authors and Affiliations
Jyothi H. Kini, Vasantakumar K. Pai, Yadav D. Bodke
Keywords
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- EP ID EP414333
- DOI 10.9790/5736-1107020108.
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