DETECTION OF HAEMOGLOBINOPATHIES USING HAEMOGLOBIN ELECTROPHORESIS IN MICROCYTIC HYPOCHROMIC ANAEMIA IN PAEDIATRIC POPULATION OF SOUTHERN ODISHA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 12
Abstract
BACKGROUND Anaemia is the most common symptom in the developing countries including India where under nutrition is prevalent besides haemoglobinopathy is also prevalent in this geographic region. Haemoglobinopathies especially thalassaemia minor present in the paediatric age group with microcytic hypochromic anaemia and hence often misdiagnosed and treated wrongly as iron deficiency anaemia. Simpler cost-effective techniques like study of haematological indices by performing Complete Blood Count (CBC) and in suspicious cases haemoglobin electrophoresis the exact diagnosis can be established at the earliest. MATERIALS AND METHODS Under aseptic condition, 5 mL of blood collected in K2EDTA Vacutainer. One part was analysed in cell count analyser. Other part was used to prepare hemolysate and subsequently gel electrophoresis. RESULTS Gel Electrophoresis is done in 210 cases of microcytic hypochromic anaemia which is detected by haemogram assay, 21% of cases were diagnosed to be thalassaemia and 79% were iron deficiency anaemia. CONCLUSION Iron-Deficiency Anaemia (IDA) is the commonest cause of microcytic hypochromic anaemia, the second being thalassaemia. Differential diagnosis is based on complete haemogram and peripheral smear. Serum iron profile study and haemoglobin electrophoresis are must for confirmation of diagnosis.
Authors and Affiliations
Meenakshi Mohapatro, Sadasiba Padhy, Manoj Kumar Patro, Rajesh Kumar Sethi
Keywords
Related Articles
- EP ID EP214022
- DOI 10.18410/jebmh/2017/127
- Views 101
- Downloads 0
COMPARISON OF LOW-DOSE BUPIVACAINE WITH FENTANYL AND BUPIVACAINE ALONE FOR SPINAL ANAESTHESIA FOR LOWER LIMB SURGERIES
BACKGROUND Bupivacaine is the widely used anaesthetic agent for spinal anaesthesia. Though, it has some advantages of producing good surgical anaesthesia and a longer half-life when compared to other local anaesthetics,t...
A STUDY OF ROUTINE ANTENATAL CARE AND ITS RELATIONSHIP WITH BIRTH WEIGHT IN DIMORIA BLOCK, KAMRUP DISTRICT, ASSAM
BACKGROUND: Globally, more than 20 million infants are born with low birth weight. The large number of factors that could theoretically influence birth weight indicates that each of them may have rather small individual...
CLINICAL STUDY OF ACUTE PANCREATITIS WITH SPECIAL REFERENCE TO RANSONS PROGNOSTIC CRITERIA
INTRODUCTION The pancreas is perhaps the most unforgiving organ in the human body and with its critical endocrine functions and its exocrine portion is a major source of extremely potent digestive enzymes Pancreatic dise...
A CASE REPORT OF CUSHING’S SYNDROME INDUCED HYPERCOAGULABLE STATE
PRESENTATION OF CASE A 25-year-old female patient presented with complaints of swelling of the left lower limb associated with pain in the left leg for 15 days duration. Patient had history of weight gain and irregular m...
NON-DESCENT VAGINAL HYSTERECTOMY ANALYSIS OF 120 CASES
To evaluate the role of non-descent vaginal hysterectomy in advancing gynaecological practice and to study the safety and feasibility of performing vaginal hysterectomy for non-prolapsed uterus as primary route in benign...