Determination of carryover and contamination for mass spectrometry-based chromatographic assays

Journal Title: The AAPS Journal - Year 2007, Vol 9, Issue 3

Abstract

The Third American Association of Pharmaceutical Scientists/Food and Drug Administration Bioanalytical Workshop, held in 2006, reviewed and evaluated current practices and proposed that carryover and contamination be assessed not only during the validation of an assay but also during the application of the method in a study. In this article, the potential risks of carryover and contamination in each stage of a bioanalytical method are discussed, to explain to the industry why this recommendation is being made.

Authors and Affiliations

Nicola C. Hughes, Ernest Y. K. Wong, Juan Fan, Navgeet Bajaj

Keywords

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  • EP ID EP681608
  • DOI  10.1208/aapsj0903042
  • Views 89
  • Downloads 0

How To Cite

Nicola C. Hughes, Ernest Y. K. Wong, Juan Fan, Navgeet Bajaj (2007). Determination of carryover and contamination for mass spectrometry-based chromatographic assays. The AAPS Journal, 9(3), -. https://www.europub.co.uk/articles/-A-681608