Determination of efficacy, adverse drug reactions and cost effectiveness of three triple drug regimens for the treatment of Helicobacter pylori infected acid peptic disease patients
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate the clinical outcome and Helicobacter pylori (H. pylori) infection status by GLQI and PCR, before and after the triple (CMO, CAO or LTC) treatment regimen. Methods: Salivary samples of 225 patients of acid peptic disease were used to determine the infection status and GLQI score before and after treatment regimen. Information regarding direct/indirect costs and side effects were determined using validated questionnaires. Results: Infection status was determined by successful amplification of 16s r RNA and Cag T genes. Positive eradication rate was 72.7% in males and 70% in females in CMO treated, 88.13% in males and 87.5% in females in CAO treated and 84.44% in males and 96.67% in females in LTC treated patients. The highest improvement in the GIQOL score after the treatment regimen was visible in the LTC treated group with a change of 65.39, followed by CAO treated patients with a change of 49.73 and CMO treated patients with an improvement of 32.18. The average cost effectiveness ratio was found to be best in the CAO treatment regimen with a ratio of 9.43 followed by LTC treatment regimen with a ratio of 11.74 and CMO with a ratio of 49.13. Side effects like diarrhea, nausea, bad taste and metallic taste were significantly enhanced in CMO (P< 0.001) when compared to CAO and LTC treatment regimens. Conclusions: The present investigation suggests that LTC is efficacious and bears less side effects, but CAO is most cost effective amongst the three treatment regimens. PCR assay can be scaled up for hospitals or clinics as a cost effective non invasive diagnostic test.
Antimicrobial activity of Hibiscus sabdariffa extract against uropathogenic strains isolated from recurrent urinary tract infections
Objective: To report the antimicrobial effect and biofilm forming capacity of the uropathogenic strains that have been isolated from recurrent urinary tract infections (UTIs) in the presence of Hibiscus sabdariffa (H. sa...
Phytochemical screening and antioxidant capacity of the aerial parts of Thymelaea hirsuta L.
Objective: To assess antioxidant activities of different aerial parts of Thymelaea hirsuta (T. hirsuta) from west Algeria, and to search for new sources of safe and inexpensive antioxidants. Methods: Samples of leaves, s...
Antibacterial effect of silver nanoparticles and capsaicin against MDR-ESBL producing Escherichia coli: An in vitro study
Objective: To evaluate the antibacterial property of silver nanoparticles (AgNPs) and capsaicin against multidrug resistant (MDR) and extended spectrum beta-lactamase (ESBL) producing Escherichia coli of bovine and poult...
Evaluation of CA-125 and other biochemical parameters in premenopausal and postmenopausal women with ovarian cancer: a hospital based study from Western Nepal
Objective: To assess the status of carbohydrate antigen 125 (CA-125) and other biochemical parameters in premenopausal and postmenopausal ovarian cancer patients. Methods: Total 64 cases, out of which 43 premenopausal an...
A mixture of honey bee products ameliorates the genotoxic side effects of cyclophosphamide
Objective: To evaluate the protective role of a mixture of honey bee products (honey, royal jelly and pollen grains) against the genotoxicity induced by the anticancer drug cyclophosphamide (CP). Methods: The study inclu...