Determination of intercellular contacts in patients with irritable bowel syndrome
Journal Title: Гастроентерологія - Year 2019, Vol 53, Issue 2
Abstract
The article presents an analysis of literature data on the violation of intestinal permeability as one of the pathogenetic factors of irritable bowel syndrome. The structure of tight junctions is considered in detail as an important element of the normal functioning of the intestinal barrier. The researches that previously studied the expression of tight junction components in patients with irritable bowel syndrome were considered. The results of our own study with the evaluation of occludin expression in patients with irritable bowel syndrome are shown. It has been found that the expression of occludin is lower in patients with irritable bowel syndrome compared with healthy individuals.
Authors and Affiliations
Yu. M. Stepanov, I. Ya. Budzak, Yu. A. Gaidar
Keywords
Related Articles
- EP ID EP582163
- DOI 10.22141/2308-2097.53.2.2019.168987
- Views 75
- Downloads 0
Histometric Features of Endocrine Islets of the Pancreas in Chronic Pancreatitis
Long-existing chronic pancreatitis (CP) in the last stages of development leads to the destruction of the endocrine pancreatic tissue, but the mechanisms of these changes are not well understood. The aim of the study was...
Morphological basis for the assessment of steatosis, steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease associated with obesity and pathology of the biliary tract
Background. The purpose was to study the histopathological features of steatosis, steatohepatitis and liver fibrosis in fatty liver disease of non-alcoholic etiology and to establish the linkages between the degree of st...
Tactics and Surgical Treatment of Obstructive Jaundice of Different Etiology
In the department of surgery of the digestive organs of State institution «Institute of gastroenterology of National aca-demy of medical sciences of Ukraine» for the period from 2003 to 2013, 567 patients with pathology...
Characteristics of changes in lipid and carbohydrate metabolism indices in patients with morbid obesity before and after surgical treatment depending on the type of surgical intervention
Background. Obesity is a chronic metabolic disease that is manifested by excessive development of adipose tissue, which has a certain range of complications and a high risk of relapse after the end of treatment. The asso...
Blood Lipids in Chronic Pancreatitis Combined with Coronary Heart Disease: Limitations of Correction
Objective. To evaluate the significance of changes in blood lipids in patients with chronic pancreatitis and coronary heart disease in the pathogenesis of comorbidity of these disorders and in the dynamics during treatme...