DETERMINATION OF RIFAMPICIN MONO-RESISTANCE MYCOBACTERIUM TUBERCULOSIS IN THE NATIONAL TUBERCULOSIS CONTROL PROGRAMME IN SANA'A CITY-YEMEN: A SIGNIFICANT PHENOMENON IN WAR REGION WITH HIGH PREVALENCE TUBERCLOISIS
Journal Title: UNKNOWN - Year 2019, Vol 4, Issue 3
Abstract
The current study was undertaken in Sana'a city, Yemen, which has one of the highest rates of Tuberculosis (TB) in the Region. The aims of this retrospective study were determined the prevalence of true RIF's mono-resistance, using the gold standard of molecular assays comparing with culture based phenotypic drug susceptibility testing (DST), and determined the associated risk factors of contracting RF gene among Yemeni TB patients. Patient's data were collected in a predesigned questionnaire which included demographic information and the relevant risk factors associated with RIF. All sputum specimens received were routinely cultured, and, underwent phenotypic drug susceptibility testing. DNA sequences specific for MTB and RIF were detected by automated molecular test. The total end treatment rate was 5.94% of the total cases (11/185). MTB gene was positive for all cases which indicate more sensitive than sputum examination; 3.2% of total patients show RIF's genes positive. Higher rate of RIF with male (5.4%), and low in female patients (1.8%). There was higher rate of RIF with age group 36-45 years (8.7%) and >15 years (7.1%). There was significant rate of RIF gene with after food drug taken (RIF=13.3%, with Odds ratio (OR)=6.4), and with DOTs program (RIF=10%, with OR=6.4). In addition, there was significant rate of RIF gene with one dose regimen (11.8%, OR=5.5). In conclusion, this study reveals the presence of RIF- M. tuberculosis in Sana’a, Yemen and most of them were observed among patients who default treatment. This is considered as a threat to TB control programme and it is recommended that strategies should be put in place in order to ensure patients’ compliance and monitoring of patients’ response to TB treatment
Authors and Affiliations
Prof. Hassan A. Al-Shamahy
Keywords
Related Articles
- EP ID EP651130
- DOI -
- Views 106
- Downloads 0
EFFECT OF PEGYLATED EDGE ACTIVATOR ON SPAN 60 BASED- NANOVESICLES: COMPARISON BETWEEN MYRJ 52 AND MYRJ 59
In recent years, Span 60 based nanovesicles have been the object of growing scientific attention as an alternative potential drug delivery system to conventional liposomes. Surface modification of nanovesicles can adjust...
FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE
Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing...
A REVIEW ON NEEDLE FREE INJECTIONS
At present scenario many researchers are working to develop technology that promises to deliver the drug in more efficient and less painful way in order to produce the therapeutic effects. Needle-free injection systems a...
A REVIEW OF BREAST CANCER RISK FACTORS
Breast cancer is a commonly diagnosed neoplastic ailment in females particularly near menopause. This ailment signifies a substantial health problem as it has influenced a large number of women. Several risk factors are...
DESIGN AND EVALUATION OF CARBAMAZEPINE LOZENGES
Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20...