Determination of vancomycin pharmacokinetics in critically ill intensive care unit patients in Malaysia: A population pharmacokinetic analysis with a nonparametric approach
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 12
Abstract
Background: The pharmacokinetics (PK) of vancomycin in critically ill intensive care unit (ICU) patients is difficult to predict due to the scarcity of data and the variable physiology of the patient cohort. Aims and Objectives: Since there are limited studies worldwide, this study is, therefore, intended to explore vancomycin population PK parameters in critically ill ICU patients in Hospital Raja Perempuan Zainab II, Kelantan, Malaysia. Materials and Methods: Vancomycin population PK in ICU patients was modeled with Pmetrics. A total of 92 samples from 45 ICU patients were included in the model building and validation. The median observations per patient were three with a range of one to four observations. The median parameters estimates obtained from the final model were used to predict individual vancomycin clearance (CL) in the validation dataset. Results: The PK of vancomycin was adequately described with a two-compartment model. Parameters included CL of 1.64 L/h, volume of distribution in central compartment of 20.0 L, rate of constant from central out to the peripheral compartment of 2.92/h, and the rate constant back from the peripheral to central compartment of 7.17/h. The developed model adequately estimated CL in the validation dataset. Conclusion: A model to describe the PK of vancomycin was developed which adequately describes vancomycin population PK in critically ill ICU patients in Kelantan. The model might be used in initiating a vancomycin dosage regimen in the type of patients similar to the present study.
Authors and Affiliations
Suzana Mustafa, Mohd Nazri Ali, Azhar Mohamed, Nazmi Liana Azmi, Afifah Azhari, Nurul Ilani Bahar, Rosaidaremanja Sukri
Keywords
Related Articles
- EP ID EP497928
- DOI 10.5455/njppp.2018.8.1030815102018
- Views 100
- Downloads 0
Assessment of anxiety depression and executive function in cases of subclinical hypothyroidism attending in a tertiary care centre
Background: Thyroid hormone has important actions in adult brain, and it is well accepted that hypothyroidism is associated with neuropsychiatric symptoms which refer to a spectrum of emotional and cognitive problems and...
Dysautonomia in heavy drinkers for more than 5 years of alcoholic consumption with intact liver function
Background: It is known for long that alcoholic liver cirrhosis is characterized by autonomic dysfunction due to the underlying liver pathology. However, alcohol can have a direct effect on the autonomic functions even b...
Correlation of Cobb’s angle with pulmonary function in idiopathic scoliosis
Background: Idiopathic scoliosis, which accounts for the 80-85% of all lateral spine curvatures, distorts the chest wall anatomy and results in functional pulmonary disability. Aims and Objectives: The aim of this study...
Identification of learning styles in 1st year undergraduate MBBS students of a private medical school in western India
Background: The challenge of imparting large amount of knowledge within a limited time period in a way it is perceived, retained, and effectively interpreted by students is considerable. This has resulted in crucial chan...
Physiologic kinetic profile of glycemic response in a single dose of clonidine
Background: Clonidine activates peripheral α-2 adrenoreceptors and influences glycemic levels. Aim and Objective: The aim and objective of the study was to determine the physiologic kinetic profile of glycemic response i...