DETERMINING THE ROLE OF NA+/CA2+ EXCHANGER IN THE RELAXANT EFFECT OF VINCANINE HYDROCHLORIDE AND PYROZALINE IODIDE ALKALOIDS
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 10
Abstract
This study presents the results of research into the relaxant effects of alkaloids vincanine hydrochloride and pyrozaline iodide on receptor-operated Ca2+ channels in smooth muscle cells of the aorta. The isometric contractile activity of smooth muscle from rat aorta was studied using mechanography. In experiments examining Na+/Ca2+ exchange activity, the effects of the studied alkaloids on receptor-operated Ca2+ channels were confirmed by the use of α-adrenoreceptor blocker phentolamine (FA) (10 µM). In these experiments, the Na+/K+-ATPase blocker ouabain (20 µM) was used to study Na+/Ca2+ exchange activity. Ouabain inhibits Na+/K+-ATPase on the plasma membrane, which leads to a decrease in the concentration gradient of Na+ and K+ ions across the membrane, enhancing reverse Na+/Ca2+ exchange and allowing the influx of Ca2+ ions into smooth muscle cells. It was concluded that the blockade of receptor-operated Ca2+ channels might play a significant role in the relaxant effect of indole alkaloids.
Authors and Affiliations
Allaniyazova Z. D. , Mirzayeva Y. T.
Keywords
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- EP ID EP750147
- DOI 10.5281/zenodo.14025886
- Views 55
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