DEVELOPMENT AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES LOADED WITH AMOXYCILLIN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
This work presents result of the development and characterization of nanoparticles for entrapping Amoxicillin, an anti microbial agent. The present study was to focus on the development of amoxicillin loaded chitosan TPP nanoparticles. Chitosan concentration and drug polymer ratio in the nanoparticles influence the physicochemical characteristic such as zeta potential, poly disparity index, and average nano size diameter or percentage encapsulation efficiency of amoxicillin. An ionization method was used to entrap amoxicillin in a chitosan-matrix. The particle size analysis indicates a uniform particle size. The encapsulation efficiency decreased with increased of amoxicillin and chitosan concentration. The drug entrapment efficiency of nanoparticles having same ratio of polymer and drug was about 88%. The physical stability of nanopaticles was good as studied over a period of three weeks. The study of the release of drug from nanoparticles exhibited a prolonged release profile (79%) as studied over 28 hr. the drug release was constant showed that formulation was long term treatment. These studies showed that chitosan can complex TPP to form stable nanoparticles for amoxicillin loading, which can be useful for microbial therapy.
Authors and Affiliations
Alok Dash , Dharmendra Singh , Jhansee Mishra , Shrikant Nirwan , Shiv Pandey
Keywords
Related Articles
- EP ID EP160964
- DOI -
- Views 122
- Downloads 0
BIOREMEDIATION OF PICOLINE BY ADAPTING P. AERUGINOSA ISOLATED FROM INDUSTRIAL EFFLUENT POLLUTED WATER
Environmental pollution implies any alteration in the surroundings but it is restricted in use especially to mean any deterioration in the physical, chemical, and biological quality of the environment. All types of pollu...
ANTINOCICEPTIVE ACTIVITY OF SRI LANKAN BLACK TEA BREW (CAMELLIA SINENSIS L.) IN RATS
The aim of this study was to investigate the antinociceptive potential of warm black tea brew of Camellia sinensis (L.) O. Kuntze (Theaceae). This was tested in rats using high grown Sri Lankan Dust grade No: 1 black tea...
PHYTOCHEMICAL INVESTIGATION OF THE SILK COCOONS OF BOMBYX MORI L.
Silk cocoons, produced by Bombyx mori L. (Bombicidae) are useful as hypotensive, expectorant, bronchodilator and attenuant drug in traditional medicine. Phytochemical investigation of the ethanolic extract of the cocoons...
LIPOSOME AS A POTENTIAL DRUG DELIVERY SYSTEM: A REVIEW
Liposomes are microscopic phospholipid vescicles made of lipid bilayer which are the drug carrier for improving the delivery of therapeutic agents. Research on liposome technology has progressed from conventional v...
PILOT STUDY FOR DETERMINATION OF BLOOD LEAD LEVELS IN PRIMARY SCHOOL CHILDREN
Exposure to lead can damage the nervous, hematopoietic, and renal systems and is particularly harmful to the developing nervous systems of fetuses and children. Most children who have elevated blood lead levels do not ha...