Development and characterization of Nicorandil loaded maltodextrin based proniosomes
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 6
Abstract
The aim of the study was to develop and characterize Nicorandil proniosomes by slurry method using the non-ionic surfactants like Span60, Brij72 and cholesterol as vesicle forming agents and maltodextrin as a carrier. The prepared proniosomes were evaluated for chemical incompatibility by FT-IR, vesicle size analysis, entrapment efficiency, in vitro drug release and in vitro drug release kinetics. Formulation was optimized based upon the entrapment efficiency and in vitro drug release. The optimized proniosomal formulation FP3 containing Span60 exhibited prolonged release profile. Fickian diffusion mechanism was observed with the FP3 which was due to the sustained release property.
Authors and Affiliations
Hidhaya Fathima K
Keywords
Related Articles
- EP ID EP330259
- DOI -
- Views 114
- Downloads 0
Antiplasmodial, anti-inflammatory and DPPH scavenging activities of extracts of the stem barks of Discoglypremna caloneura (Pax) Prain
In this study, the stem bark of Discoglypremna caloneura was subjected to phytochemical study and biological activity screenings. The hexane and ethyl acetate extracts exhibited significant inhibitory activities on strai...
Chemical and Bio-guided Evaluation of Some Natural Resins as Potential Antitumor Agents
Naturally occurring resins have beneficial pharmaceutical and nutraceutical properties. Based on the Ethnopharmacological literature, several species of natural resins used in traditional medicine were collected. In this...
A Study on Appendageal skin tumors in tertiary health centre
Cutaneous appendageal tumors are a large diverse group of tumors that are commonly classified according to their state of appendageal differentiation- eccrine, apocrine, follicular and sebaceous. Most appendageal tumors...
Isolation, Screening and Identification of two Streptomyces soil isolates exhibiting strong antimicrobial activities against Extended Spectrum Beta Lactamase (ESBL) producers
One of the urgently needed antimicrobials is those antagonizing extended-spectrum beta-lactamase (ESBL) producers as they represent an emerging global health threat. Objective: Screening soil bacterial isolates for anti-...
Knowledge and practice towards hygiene and sanitation among children
As the famous sayings “Health is wealth” and “children are future of nation”, we started our study to see the awareness about health in children. Hygiene practices and sanitation play most important role in to live healt...