Abstract

The purpose of this research work was to formulate an anti diabetic and anti hypertensive in a single dosage form i.e. Metformin HCl in sustained release layer and Ramipril in immediate release layer of the bilayer tablet. The tablets were prepared using Hydroxypropylmethylcellulose (HPMC K4M & HPMC K100M, METHOCEL 40- 101,METHOCEL K15MPCG) and hydroxyl ethyl cellulose(HEC) an as release retarding polymers in various combination and concentrations. The effect of different super disintegrants on immediate release in various concentrations was also studied. Nine formulations of immediate release layer were prepared using SSG, CCS, Crosspovidine superdisintegrants with different proportions and were evaluated for different parameters. Among the nine formulations R6 containing CCS as disintegrant showed a better release of 99.73% for 45 mins was selected. Using this R6 formulation Nine formulations of sustained release layer of Metformin.HCL was prepared with different Hydroxypropylmethylcellulose (HPMC K4M & HPMC K100M, METHOCEL 40-101,METHOCEL K15MPCG) and hydroxyl ethyl cellulose(HEC) polymers and evaluated. Among nine formulations of bilayered tablets RM9 was showed 99.32% at the end of 12hrs was selected as optimized formulation. This optimized formulation was evaluated for parameters like , thickness, hardness, friability, weight variation, drug content, in vitro drug release and stability and results were found to be within limits

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