DEVELOPMENT AND EVALUATION OF PARACETAMOL SUPPOSITORIES
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Suppositories are supposed to be efficient and effective dosage form specially to dispense analgesics and antipyretics. Paracetamol is widely used as antipyretic and analgesic. When used in the form of suppositories it produces rapid effects due to its quick absorption through the rectal route. During the present study, Paracetamol suppositories are formulated by using different ratios of Polyethylene Glycol 1000 and polyethylene Glycol 4000. The in vitro drug release rate studies were carried out by using B.P dissolution apparatus. The average weight variation of different ratios of Paracetamol suppositories are; 2.5168 gm for the ratio of (3.35-0.65), 2.5193 gm for the ratio of (3.00-1.00), 2.5308 gm for the ratio of (2.00-2.00), 2.5378 gm for the ratio of (1:00-3.00), 1.83 gm for marketed suppository (Napa). The average hardness of different ratios of Paracetamol suppositories are; 6.67 kg for the ratio of (3.35-0.65), 7.21 kg for the ratio of (3.00-1.00), 8.44 kg for the ratio of (2.00-2.00), 8.27 kg for the ratio of (1:00-3.00), 6.93 kg for marketed suppository (Napa). The melting time of different ratios of Paracetamol suppositories are; 27 minutes at 37°C for the ratio of (3.35-0.65), 37 minutes at 37°C for the ratio of (3.00-1.00), 1 hour at 37°C for the ratio of (2.00-2.00), 1 hour and 15 minutes at 37°C for the ratio of (1:00-3.00), 28 minutes at 37°C for marketed suppository (Napa). The % release of different ratios of Paracetamol suppositories are; 99.05% in 30 minutes for the ratio of (3.35-0.65), 98.53% in 30 minutes for the ratio of (3.00-1.00), 97.79% in 30 minutes for the ratio of (2.00-2.00), 96.33% in 30 minutes for the ratio of (1:00-3.00), 99.26% in 30 minutes for the ratio of marketed suppository (Napa) respectively. It is expected that present work will be helpful for the selection of appropriate ratio of suppository bases to get the maximum % release of drug.
Authors and Affiliations
Tara Chand Khatri
Keywords
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