Development of a medicinal form with the essential oil of Thyme for the prophylaxis of gynecological diseases

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Development of a medicinal form with the essential oil of Thyme for the prophylaxis of gynecological diseases

Journal Title: Вісник фармації - Year 2019, Vol 98, Issue 2

Abstract

Aim. To determine parameters of the pharmaceutical availability of the herbal medicine for the prophylaxis of gynecological diseases – egg-shaped vaginal suppositories with the essential oil of Thyme (the constants characterizing the kinetics of release and the half-release of thymol (T1/2)). Materials and methods. The study object was egg-shaped vaginal suppositories with the essential oil of Thyme. Using the dialysis method through a semi-permeable membrane and the titrimetric method of analysis thymol was determined in a medicinal form in the in vitro experiments. The antibacterial properties and the bacteriostatic effect of the samples of the essential oil and egg-shaped vaginal suppositories with the essential oil of Thyme were studied using the laboratory methods of analysis. Results and discussion. The qualitative therapy of inflammatory and bacterial gynecologic diseases in women has great medical and social importance. The use of medicinal plants and biologically active substances on their basis is one of the most widely spread methods for treating these pathologies. Representatives of Thymus L. (Thyme) genus of Lamiaceae L. family contain high concentrations of biologically active substances of phenolic, terpenes and flavonoid origin exhibiting a wide range of the pharmacological activity (anti-inflammatory, antibacterial, antioxidant, etc.) and possessing rather low toxicity. Conclusions. The estimation of efficiency and quality of a new medical form of egg-shaped vaginal suppositories with the essential oil of Thyme is given. The parameters of pharmaceutical availability required when searching a new herbal medicine have been conducted. The optimal composition of the herbal medicine developed has been confirmed. The modern methods of research have been used. In the in vitro experiments the use of repeated research has allowed us to build the reliable graphs of the dependence of the concentration of thymol release from time. The high antibacterial and antimycotic effects of the essential oil and egg-shaped vaginal suppositories with the essential oil from Thyme have been determined in relation to strains of Candida pathogenic fungi, as well as bacilli and bacteria of St. aureus, St. pyogenes, B. anthracoides, E. coli, Kleb. pneumonium.

Authors and Affiliations

L. A. Fukleva, L. O. Puchkan

Keywords

vaginal diseases; essential oil of Thyme; pharmaceutical availability; antibacterial activity

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EP ID EP657570
DOI 10.24959/nphj.19.8
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