DEVELOPMENT OF A TABLET FORM OF LIU WEI DI HUANG EXTRACT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: Develop an effective and stable tablet form of Liu Wei Di Huang (LWDH).Methods: LWDH extract was obtained by decoction (TC) and reflux with water (WR). Extracts were concentrated and analyzed by HPLC-PDA using loganin as the bioactive marker. Adsorbents, tablet strength and friability, and tablet quality and stability were evaluated.Results: Extraction of LWDH formula from raw materials using WR yielded higher concentrations of loganin than TC. The best formulation of LWDH tablets included Avicel®PH101, corn starch, purified talcum, magnesium stearate and Cab-osil® with about 97.40% of the label amount of active marker. Excluding moisture from the product reduced marker degradation, suggesting a product shelf life 12+months. Finished tablets were uniform in weight, friability, disintegrated in<30 min, had good microbial and heavy metal contamination safety profiles and was stable.Conclusions: Extraction of LWDH formula using reflux with water produces higher yields than decoction. A suitable tablet formulation consists of dried water extract (38.83%), corn starch (29.13%), Avicel®PH101 (29.13%), purified talcum (0.97%), magnesium stearate (0.97%) and Cab-osil® (0.97%) prepared by wet granulation. Excluding moisture from the product reduces product degradation, suggesting a shelf life of 12+months. LWDH tablets avoid traditional formulation problems (high dosages, unacceptable taste and odor, lack of product uniformity, contamination with microorganisms and heavy metals), and are a good alternative for patients and TCM practitioners.Â
Authors and Affiliations
Vorawut Jearasakulpol, Pramote Tipduangta, Supanimit Teekachunhatean, Natthakarn Chiranthanut, Sunee Chansakaow
Keywords
Related Articles
- EP ID EP578565
- DOI -
- Views 76
- Downloads 0
GENERATION DEPENDENT TARGETING POTENTIAL OF DONEPEZIL LOADED POLY (PROPYLENEIMINE) DENDRIMER THROUGH GOAT NASAL MUCOSA
Objective: In the domain of nano drug delivery, dendrimers are the most explored bioactive polymeric carrier system. The present work was aimed to study the diffusion potential of different generations of Poly (propylene...
EVALUATION OF ANTI-RENOTOXIC RESPONSES IN FLOWERS OF INDIAN LOTUS (NELUMBO NUCIFERA GAERTN.)
Objective: The present study was formulated in order to evaluate anti-renotoxic responses in flowers of an Indian lotus (Nelumbo nucifera Gaertn.)Methods: Gentamicin at a dose of 100 mg/kg/day was used intra-peritonealy...
PROTECTIVE EFFECTS OF Α - CRYSTALLIN ON Β - AMYLOID (Aβ) INDUCED TOXICITY
Objectives: To investigate the protective role of α-crystallin against β-amyloid aggregation.Methods: In vitro spectroscopic methods and cell culture studies were done to validate our objective.Results: The molecular b...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC DETERMINATION OF CEFPODOXIME PROXETIL IN PURE AND TABLET DOSAGE FORMS THROUGH ION-PAIR COMPLEX FORMATION USING BROMOTHYMOL BLUE
Objective: A simple, direct and accurate spectrophotometric method has been developed for the determination of cefpodoxime proxetil (CEFP) in pure and pharmaceutical formulations by complex formation with bromothymol blu...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF PROPRANOLOL HYDROCHLORIDE
Objective: The present study was to formulate and evaluate of sustained release bilayer tablets of anti-hypertensive drugs propranolol hydrochloride.Methods: The tablets were prepared by direct compression method by usin...