Development of CelecoxibTransfersomal gel for the Treatment of Rheumatoid Arthritis
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for various parameters including vesicle shape, size and size distribution, surface morphology, entrapment efficiency, in-vitro and ex-vivo drug release and in-vivo anti-inflammatory activity. Vesicles were also evaluated for skin irritation study and permeation studies.Results of all the studies suggested that CelecoxibTransfersomal gel formulation was therapeutically effective drug delivery system for treatment of Rheumatoid Arthritis.
Authors and Affiliations
Preeti| Nanomedicine Research Center, Department of Pharmaceutics, Rajendra Institute of Technology and Sciences, Institute of Pharmacy, Sirsa, Haryana, India, Murugesan Senthil Kumar| Himachal Institute of Pharmacy, Paonta sahib, HP. 173025, India
Keywords
Related Articles
- EP ID EP14134
- DOI -
- Views 406
- Downloads 18
Synthesis and antimicrobial activity of some newer semicarbazone analogues
On the basis of literature review Semicarbazones have been potent in activities such as antifungal, antibacterial, antituberculosis, anticancerous etc. Till date various works has been done however still there is tremend...
Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system
Objective: To deal with the formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet containing Carica papaya, Vitex negundo, Moringa oleifera and Boswellia serrata used a...
Colon targeted drug delivery system: A review on current approaches
The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatmen...
Evaluation of phytoconstituents and assessment of adaptogenic activity in vivo in various extracts of Rhododendron arboreum (leaves)
Natural products particularly of plant origin with antistress property and nutraceutical value have become the focus of scores of scientific investigation in recent times. Against this background the present study was...
A overview: non-steroidal anti-inflammatory drugs and mechanisms
The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabol...